Each business day, TheStreet.com Ratings TheStreet.com Ratings compiles a list of the top five stocks in one of five categories -- fast-growth, all-around value, large-cap, mid-cap and small-cap -- based on data from the close of the previous trading session. Today, large-cap stocks are in the spotlight.These are stocks of companies with market capitalizations of over $10 billion that rank near the top of all stocks rated by our proprietary quantitative model, which looks at more than 62 factors. In addition, the stocks must be followed by at least one financial analyst who posts estimates on the Institutional Brokers' Estimate System. The stocks are ordered by their potential to appreciate. Note that no provision is made for off-balance-sheet assets such as unrealized appreciation/depreciation of investments, market value of real estate or contingent liabilities that might affect book value. This could be material for some companies with large underfunded pension plans. Genentech ( DNA) is a biotechnology company that discovers, designs, manufactures, and commercializes a number of biotherapeutics, such as Rituxan, an antibody that is used in the treatment of non-Hodgkin's lymphoma. We have rated the company a buy since August 2008, based primarily on its growth, solvency, efficiency, and solid stock price performance. For the fourth quarter of fiscal 2008, Genentech reported that its U.S. product sales rose 11% when compared to the same quarter of fiscal 2007. Revenue rose 24.9% year over year, and this growth appears to have helped boost EPS, which improved 47.5% from 59 cents to 87 cents. We feel that the company's trend of positive EPS growth should continue. Net income also increased in the fourth quarter, rising 47.7% from $631 million in the prior year's quarter to $932 million in the most recent quarter. Genentech has a very low debt-to-equity ratio of 0.2, which implies that the company has successfully managed its debt levels.