Cytomedix ( GTF) was one of the biggest winners, both among small-cap stocks and overall, amid a mostly bullish session Friday.

Shares of the Rockville, Md., biotech company skyrocketed some 125% after the Food and Drug Administration approved its wound-closing AutoloGel System for use on various sorts of ulcers, as well as for the management of mechanically or surgically debrided wounds. Shares soared $1.47 to $2.64.

HandHeld Entertainment ( ZVUE) also rode high after the maker of Zvue portable media players announced that comScore Media Matrix has named it the "fastest growing Web property" for August, citing a 327% surge in unique U.S. visitors to its Web-based network vs. July. Shares of the San Francisco-based company vaulted more than 65% to $2.90.

Elsewhere, Cowen & Co. started coverage on Savient Pharmaceuticals ( SVNT) with an outperform rating, saying its proposed gout treatment Puricase -- meant for patients who haven't responded to other treatments -- is promising and has significant revenue potential. Shares leapt 81 cents, or 6.1%, to $14.06.

The Russell 2000 and the S&P SmallCap 600 added 0.4% and 0.1%, respectively, boosted by gains at both Savient and at Genesco ( GCO), which filed a lawsuit seeking to force Finish Line ( FINL) to close the $1.5 billion merger the footwear retailers inked in June.

Earlier this month, UBS -- which is slated to fund the takeout -- told Finish Line that it was " extremely concerned " about Genesco's financial health and might withhold financing if Genesco has undergone a "Material Adverse Effect" as defined in the related agreement.

Shares of Nashville, Tenn.-based Genesco were up 1.5% to $47.46; Finish Line, based in Indianapolis, slipped 0.6% at $5.26.

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