Editor's Note: In this feature from Stockpickr, we highlight lists of stocks that have made new highs, lows or seen other unusual activity.

Biggest % Gainers: QEP ( QEPC) launched 63% after the maker of tools for flooring and tiling reported an increase in quarterly earnings. First-quarter earnings rose to $900,000, or 23 cents a share, from $300,000, or 8 cents a share, a year earlier. Tuesday, shares traded $4.06 higher to close at $10.52.

52-Week Highs: Pogo Producing ( PPP) rose to a 52-week high of $58.29 after independent oil and gas producer Plains Exploration & Production ( PXP) said Tuesday it would acquire the exploration company. The $3.6 billion stock-and-cash deal surprised analysts and forced shares $7.02, or 14% higher to close at $57.50.

Rising on Unusual Volume: Amid in increase of nearly 1,000% in average volume, shares of Keystone Automotive ( KEYS) surged after the auto-parts distributor agreed to be acquired by LKQ ( LKQX) for about $811 million in cash, or $48 a share. The price represents a 10% premium to Keystone's closing price of $43.61 on Monday. Tuesday, shares finished trading up $3.19, or 7.3%, at $46.80.

Biggest % Losers: Metabasis Therapeutics ( MBRX) sunk on news that its type 2 diabetes candidate revealed disappointing phase II results. A decision by Schering-Plough ( SGP) to terminate its drug development agreement with the company on a hepatitis B treatment also added to the selloff. Shares closed down $3.75, or 54%, at $3.15.

52-Week Lows: Metabasis also dropped to a 52-week low of $2.75 during Tuesday's downslide.

Stocks With Unusual Option Activity: Research In Motion ( RIMM) experienced unusual options activity Tuesday. The stock traded 1.5% higher to close at $230.07.

Latest Activist Situations: In a 13G filing on Flamel Technologies ( FLML), Daniel Loeb's Third Point disclosed a 9.2% stake (2.2 million shares) in the company. This is up from the 225,000-share stake the firm disclosed at the quarter ended March 31. Tuesday, the biopharmaceutical company dropped 3.5%, closing down 79 cents at $21.39.

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