Editor's note: In this feature from Stockpickr, we highlight lists of stocks that have made new highs, lows or seen other unusual activity.

Latest Activist Situations: A report in the Chicago Sun-Times said Sears Holdings ( SHLD) could be a target for activist investor William Ackman, who runs Pershing Square Capital. An earlier report in the New York Post speculated that Anheusier-Busch ( BUD) would be his target. Wednesday, Sears was down 0.5%, closing at $177.58.

Biggest % Gainers: San Diego's Inovio Biomedical ( INO) added 24%, recovering some of Tuesday's losses. Shares increased 53 cents to $2.73, after the company reported positive preclinical results for DNA vaccines using its electroporation technology, which improved immune responses against malaria, HIV and hepatitis C vs. traditional vaccine-delivery methods.

Biggest % Losers: TowerStream ( TWER), a commercial wireless Internet provider, plummeted 33% after reports it would sell $40 million in stock to investors at a below-market price of $4 per share. President and CEO Jeff Thompson said the company plans to use the offering's proceeds to build out its target markets. The stock ended trading down $1.92 to $3.95.

52-Week Highs: The triple-digit drop in the Dow did not affect Johnson Controls ( JCI), which added 4% after several analysts reported a buy rating. The car component maker's shares increased $4.31, ending up at a new 52-week high of $112.76.

52-Week Lows: Jabil Circuit ( JBL) has been on a downward slide since last week, when the company announced lower-than-expected earnings and slashed full-year guidance. The St. Petersburg electronic manufacturer sunk 3% Wednesday, landing at a 52-week low of $21.00.

Rising on Unusual Volume: Apparel retailers declined on Wednesday, but not Guess? ( GES). The company's shares gained 3.8%, based on impressive first-quarter earnings and inflated full-year guidance. Shares were trading at 449% of normal volume, finishing up $1.80 to $49.22.

Stocks with Unusual Option Activity: Eastman Kodak ( EK) was experiencing unusual option activity. Shares of the photographic services company traded down 2.29%, or 61 cents, to $25.97.

Forum of the Day

manoasteve strikes up a discussion about Mining and Commodities.

Do You Know the Answer?

david schindler asks, What Stocks are people buying in Wednesday's dip? schindler said he just bought Annaly Capital Management ( NLY), 10% off its highs.

Feeling Lucky?

And finally, try picking a random portfolio suited to do-it-yourselfers with more detailed analysis at I'm Feeling Lucky.

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