Editor's note: In this feature from Stockpickr, we highlight lists of stocks that have made new highs, lows or seen other unusual activity.

52-Week Highs: Research in Motion ( RIMM), maker of the Blackberry, surged to $159.89 Thursday, after a Merrill Lynch analyst upped his target price for the company.

Biggest % Gainers: Pacificnet ( PACT) jumped 36% to $5.34 after the gaming technology company posted its first profitable quarter since venturing into the gaming technology business. The company posted first-quarter profits of 3 cents a share on revenue of $9.3 million.

Rising on Unusual Volume. Shares of Vodafone Group ( VOD) were trading at volume 137% higher than normal and closed 2% higher at $30.36. Speculation of more acquisitions in the telecommunications industry sparked the heavy activity.

Latest-Activist-Situations: Daniel Loeb's Third Point hedge fund lowered its stake in biopharmaceutical concern Acorda Therapeutics ( ACOR) by more than half, to 4.1%. Third Point had earlier asked the company's management to retain an investment bank for the purposes of exploring a sale.

Biggest % Losers: Northfield Laboratories ( NFLD) experienced substantial loses for the second consecutive day, plunging 21% to $1.50 after Polyheme, a blood substitute, revealed disturbing news. In phase III trials, Polyheme, the company's only product, was found to highly increase the rate of heart attacks in patients given the blood substitute.

52-Week Lows: Varian Medical Systems ( VAR), a medical device maker, slumped to $40.24 after announcing it had acquired Bio-Imaging Research, an X-ray imaging company, for $21 million.

Stocks With Unusual Option Activity: Apple ( AAPL), closing Thursday at $110.69 and awaiting the launch of the iPhone later this year, was experiencing unusual options activity.

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