Updated from 1:49 p.m. EDT

Targeted Genetics ( TGEN) skyrocketed more than 66% Thursday after the biotech company swung to a fourth-quarter profit and sped past Street expectations. The Seattle-based company earned $808,000, or 8 cents a share, on revenue that more than doubled to $4 million. The company recorded a loss of $3.6 million, or 41 cents a share, in the year-ago period. The sole analyst's estimate called for a loss of 13 cents a share on $3.8 million in sales, according to Thomson Financial. Shares rose $1.70 to $4.27.

Misonix ( MSON) jumped after the Farmingdale, N.Y., company's Sonablate 500 product successfully removed cancerous tissue from prostate-cancer patients in a Britain-based study. In the study of the high-intensity ultrasound technology, test subjects exhibited 100% continence and potency in follow-up exams. Specifics on the trial weren't provided. Shares of Misonix rose 43 cents, or 7.4%, to $6.22.

Shares of etrials Worldwide ( ETWC) gained after two unnamed European pharmaceutical companies agreed to etrials' clinical-trial software and services for wide-ranging clinical studies on depression and gaucher disease. Shares of the Morrisville, N.C.-based company climbed 33 cents, or 7.4%, to $4.82.

KMG America ( KMA) lost 43.8% after A.M. Best cut the life-insurer's outlook to negative from stable, despite reiterating its A- (or excellent) financial-strength rating. The Minneapolis-based company said this may prevent it from competing in certain markets, and that it's "no longer comfortable" with prior 2007 earnings guidance until it finishes a review of the full consequences. Shares were down $3.80 to $4.87.

If you liked this article you might like

Lackluster Finish for U.S. Stocks

Lackluster Finish for U.S. Stocks

Stocks Continue to Waver at the Flat Line

Stocks Continue to Waver at the Flat Line

Oil Slides as Stocks Post a Mixed Showing

Oil Slides as Stocks Post a Mixed Showing

Stocks Flutter Near the Flat Line

Stocks Flutter Near the Flat Line

Wall Street Falls Amid Inflation Talk

Wall Street Falls Amid Inflation Talk