Shares of biotech Iomai ( IOMI) soared nearly 25.3% to $6.39 after the company said it will receive a contract from the Department of Health and Human Services to develop a patch to improve the efficacy of small amounts of flu vaccine, to help cover more individuals in the event of a pandemic. The company could receive research costs plus a fix fee totaling $128 million. The department has already allotted $14.5 million to cover performance under the contract through March 31, 2008, Iomai says. Shares of drug developer Xoma ( XOMA) jumped 6.4% to $2.50 after the company said it's expanding its collaboration with Schering-Plough ( SGP) in the development of antibodies to treat cancer and immune diseases. Shares of Angiotech Pharmaceuticals ( ANPI) gained 5% to $9.03 after a Dutch court ruled in favor of the company and partner Boston Scientific ( BSX) in a patent dispute with Conor Medsystems ( CONR). Shire's ( SHPGY) shares were up 1.4% to $64.45 after the pharmaceuticals company said it received regulatory approval for its ulcerative colitis drug Lialda. Shares of Neurocrine Biosciences ( NBIX) gained 5% to $12.33 after the stock was upgraded to overweight from equal weight by Lehman Brothers health care analyst Jim Birchenough. Among other health stock winners Wednesday were GlaxoSmithKline ( GSK), up 1.3% to $55.23; Johnson & Johnson ( JNJ), 1% higher to $67.22; Abbott ( ABT), rising 1.4% to $51.32; Wyeth ( WYE) up 1.4% to $51.17; Novogen ( NVGN), gaining 4.5% to $12.10; and Geron ( GERN) growing 3.7% to $8.97.