Online insurance marketplace InsWeb ( INSW - Get Report) was sharply higher after it said its fourth-quarter loss would be significantly narrower than both the third quarter and the same period a year ago. Revenue for the fourth quarter should be in the range of $5.7 million to $6 million, compared with $5.8 million a year earlier. Shares of InsWeb were up 32% to $3.30.

Nymox Pharmaceutical ( NYMX - Get Report) surged on word it's developing a product called NXC-4720 that's capable of reducing the level of E. coli O157:H7 contamination in food by more than 99%. The company's announcement comes on the heels of a number of E. coli contamination cases at Taco Bell restaurants in the Northeast. Nymox was gaining 9.5% to $3.56.

Shares of Tweeter Home ( TWTR - Get Report), an electronics retailer, were sinking after Best Buy ( BBY - Get Report) missed third-quarter earnings expectations and said competition was eating into its margins. Tweeter Home was falling 13% to $2.15.

Matrixx Initiatives an over-the-counter phamaceutical company, was dropping after the company said this year's sales and net income probably won't reach even the low end of its projections because of a slow start to the cold season. The company now expects net sales growth of 15% to 20% from last year's $90.5 million and net income growth of 2% to 7% from $7.6 million in 2005. Matrixx was losing 11.4% to $16.30.