Sangamo Biosciences ( SGMO) was one of Friday's small-cap winners, climbing 5% on speculation that the drug developer could a takeover target.

Navdeep Jaikaria, a biotech analyst at Rodman & Renshaw, told BusinessWeek he believed Sangamo could be in the crosshairs of a big pharmaceutical company, noting that Sangamo currently has development deals with Pfizer ( PFE) and other companies. Shares of the biotech were trading up 38 cents to $7.90.

Mothers Work ( MWRK) slumped after the Philadelphia-based maternity apparel company said CEO Dan Matthias and President and Chief Operating Officer Rebecca Matthias sold 476,220 shares of the company's stock. The Matthiases said they sold the shares for estate planning, personal asset diversification and liquidity purposes. They still own 359,324 shares after the sale. "Rebecca and I have strong continued confidence in the Mothers Work business strategy and future," Dan Matthais said in a statement, adding that the sales would "broaden the liquidity of the company's stock." Shares were trading down $3.35, or 6.6%, to $47.50.

Shares of Pointer Telocation ( PNTR) surged 87%, continuing a climb from Wednesday. Earlier this week, the company said it swung to a third-quarter profit of $449,000, or 14 cents a share, compared with a loss of $348,000, or 14 cents a share, last year. Revenue rose 7.2% from a year ago to $11.2 million. Shares of Pointer, a provider of vehicle services, recently were up $6.94 to $14.94.

Systemax ( SYX) shares rose after the Port Washington, N.Y.-based computer distributor posted a big jump in second-quarter earnings and revenue. For the quarter ended June 30, the company earned $7.1 million, or 19 cents a share, on revenue of $547.2 million. During the year-earlier period, Systemax earned $1.5 million, or 4 cents a share, on revenue of $506.1 million. Shares were up $2.03, or 17%, to $14.15.

Journal Register ( JRC) declined after the newspaper chain operator was downgraded by Matrix Research to sell from hold. Shares were trading down 21 cents, or 2.6%, to $8.04.

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