Shares of Trimeris ( TRMS) jumped 12% in late trading Thursday after the drug developer reported that it swung to a fourth-quarter profit. The company reported a profit of $3.8 million, or 17 cents a share, compared with a loss of $5.7 million, or 27 cents a share, a year earlier. Revenue surged to $7.96 million from $536,000. Analysts polled by Thomson First Call had expected the company to post a loss of 1 cent a share, with $6.29 million in revenue. The company said results were boosted by strong sales of Fuzeon, its HIV drug that it co-developed with Roche. Trimeris said it expects continued profitability in 2006. Shares gained $1.36 to $13.10 in after-hours trading.

Universal Display ( PANL) posted a wider-than-expected fourth-quarter loss, sending shares down after hours. The company, a maker of light-emitting diode systems for flat-panel displays, said its loss swelled to $4.6 million, or 17 cents a share, from $3.5 million, or 11 cents a share, a year earlier. Revenue rose to $2.3 million from $1.7 million. Analysts, on average, expected a loss of 13 cents a share and revenue of $3 million. Shares sank $1.05, or 7%, to $13.80.

Shares of Union Drilling ( UDRL) rose after the offshore-drilling company reported earnings that easily topped Wall Street's prediction. The company posted fourth-quarter income of $4.3 million, or 23 cents a share, compared with $1.5 million, or 12 cents share, a year ago. Excluding a gain on a sale, earnings would have been 21 cents a share, well above analysts' target of 8 cents. Revenues surged to $46.5 million from $18.8 million. Looking ahead, the company said it anticipated "continued sequential improvements." Shares advanced $1.10, or 8.7%, to $13.80 in after-hours trading.

Quantum Fuel Systems ( QTWW) shares plummeted after the alternative fuel-systems maker posted third-quarter results that fell well short of analysts' projection. The company's loss for the quarter ended Jan. 31 widened to $10.8 million, or 20 cents a share, from $2.9 million, or 9 cents a share, a year ago. Analysts were looking for the company to post a loss of 9 cents a share in the latest quarter. Revenue jumped to $36 million from $5.4 million a year earlier, but was well below Wall Street's target of $51 million. Shares fell 66 cents, or 16%, to $3.38 in late trading.

Big 5 Sporting Goods ( BGFV) retreated after the retailer posted a drop in its fourth-quarter profit. The company's earnings fell to $7.7 million, or 34 cents a share, from $9.5 million, or 42 cents a share, a year ago. The results included costs of roughly $4.5 million, or 12 cents a share, related to the company's transition to a new distribution center. Big 5's sales rose to $218.9 million from $217.6 million a year ago, while same-store sales increased 1.5%.

Analysts were looking for the company to post earnings of 33 cents a share, with sales of $218.4 million. The company said it expects same-store sales growth in the low- to mid-single digit percentage range for the first quarter and fiscal year. It forecast full-year earnings of $1.23 to $1.33 a share, including unspecified costs related to the distribution center and stock options. Analysts, whose estimates often exclude one-time items, target earnings of $1.62 a share. Big 5 shares fell $1.73, or 8.6%, to $18.50 in after-hours trading.