Dyadic International ( DIL) shares rose nearly 13% to $1.85 a day after the company said it restructured an agreement with research partner TNO Quality of Life. The move effectively eliminates a profit-sharing and royalty-rights arrangement related to Dyadic's fungal high-throughput screening system and also settles an outstanding debt that a Dyadic unit owed to TNO.

Shares of Celgene ( CELG) rose 4.6% to $60.12 after the Food and Drug Administration approved Revlimid for treating transfusion-dependent anemia. The company also said Sol Barer will replace John Jackson as CEO on May 1 and set plans for a 2-for-1 stock split.

CAS Medical Systems ( CASM) received clearance from the Food and Drug Administration to market its Near Infrared Spectroscopy Adult Cerebral Oximeter Monitor. The news sent shares of CAS higher by $2.09, or 31%, to $8.84. The product is a continuous, noninvasive monitor measuring absolute levels of brain tissue oxygen saturation, and the company plans to start selling it in late 2006.

Shares of Affymetrix ( AFFX) surged almost 7% to $46.72 after Standard & Poor's said the company will take the place of Whole Foods in the MidCap 400. Whole Foods is being moved to the S&P 500. Volume in Affymetrix was about two-and-a-half times the normal amount for a full session.

Prospect Medical Holdings ( PZZ) skyrocketed 34% to $5.75 after the company posted fourth-quarter revenue of $35.5 million, up from $35 million in the same period last year, and said net income rose to $1 million, or 13 cents a share from $908,000, or 11 cents a share, a year ago.

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