Genentech ( DNA) also is developing a VEGF-type drug for wet AMD. The drug, called Lucentis, is in late-stage clinical testing and must be injected into the eye every four weeks. Genentech is collaborating with Novartis. A company working on a different type of wet AMD drug is Alcon ( ACL), which submitted its application to the FDA on Thursday. Alcon's drug is called Retaane. The Swiss drug and device company announced in mid-October that a key test of Retaane showed no difference from the QLT-Novartis photodynamic therapy. At the time, Alcon vowed it would seek FDA approval by year-end, saying there were "controllable factors" in the clinical trial that "negatively impacted the overall results" of its study. Retaane is a steroid that fights the development of new, unwanted blood vessels. Retaane is administered every six months. Instead of being injected into the eyeball, Retaane is delivered via a tube directly in contact with the outer surface of the sclera, the fibrous outer envelope that covers much of the eyeball. Alcon is hoping this approach will give Retaane a marketing edge over Eyetech's drug. Other companies working on wet AMD treatments include Genaera ( GENR), Iridex ( IRIX) and Miravant Medical Technologies ( MRVT).