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Victoria's Secret rose and Bath & Body Works fell after the two companies, formerly part of L Brands, on Tuesday had begun trading separately.
AMD was joined by Nvidia and other chipmakers on an extended rally, as the industry shortage continues to boost their finances.
Moderna jumped a day before the vaccine maker reports earnings, helped by regulatory progress and the surging delta variant of COVID-19.
Novavax, BeyondSpring, New York Times, United Therapeutics and Denny's are five top stock gainers for Wednesday.