Updated with information about Barnes & Noble's deal with Microsoft, Hologic's acquisition of Gen-Probe.

NEW YORK --

Microsoft

(MSFT) - Get Report

will make a $300 million investment for a 17.6% stake in a new

Barnes & Noble

(BKS) - Get Report

subsidiary that will bring together the bookseller's digital and college businesses.

The partnership includes a NOOK application for Windows 8, Barnes & Noble and Microsoft said.

Shares of Barnes & Noble soared 72.08% in premarket trading Monday to $23.54. The stock has fallen 5.52% year to date.

Microsoft shares ticked up 21 cents, or 0.66%, in premarket trading to $32.19. The stock has risen 23.19% year to date.

Hologic

(HOLX) - Get Report

agreed to acquire

Gen-Probe

(GPRO) - Get Report

for $82.75 a share in a cash, or about $3.7 billion..

Shares of Gen-Probe rose 19.33% in premarket trading Monday to $82. The stock has risen 16.23% year to date.

Hologic shares increased 4.8% in premarket trading to $22.25. The stock has gained 21.25% year to date.

NYSE Euronext

(NYX)

said first-quarter adjusted earnings declined 32%.

The exchange saw a slowdown in trading, particularly in its derivatives trading unit, and was hit by costs associated with its failed merger with Germany's

Deutsche Boerse

.

Adjusted profit in the quarter was 47 cents a share; analysts were looking for 48 cents.

Humana

(HUM) - Get Report

, the health care company, reported first-quarter earnings Monday of $248 million, or $1.49 a share, down from year-earlier earnings of $315 million, or $1.86 a share.

First-quarter earnings included a gain of 3 cents a share from previous medical claim reserves; year-earlier earnings included a gain of 31 cents a share.

Humana was expected by analysts to report first-quarter earnings of $1.52 a share.

Humana raised its full-year 2012 guidance to between $7.55 a share and $7.75 a share from a previous range of between $7.50 a share and $7.70 a share. Analysts were calling for earnings of $7.99 a share.

Shares of Humana fell 4.35% in premarket trading Monday to $84. The stock has risen 0.24% year to date.

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Watson Pharmaceuticals

(WPI)

reported non-GAAP first-quarter earnings Monday of $208.8 million, or $1.64 a share, up from year-earlier earnings of $111.9 million, 89 cents.

Analysts were expecting first-quarter profit of $1.60 a share on revenue of $1.48 billion.

Shares of Watson Pharmaceuticals were flat in premarket trading on Monday. The stock has risen 26.22% year to date.

Watson Pharmaceuticals last week agreed to buy competitor

Actavis

for $5.6 billion.

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Warner Chilcott

(WCRX)

, the drugmaker, is weighing options including a possible sale after receiving interest from strategic and private-equity buyers, according to people with knowledge of the matter,

Bloomberg

reported.

Shares of Warner Chilcott gained 15.86% in premarket trading Monday to $21.77.

Pall

(PLL) - Get Report

agreed to sell certain blood collection assets to

Haemonetics

(HAE) - Get Report

for about $550 million.

Haemonetics, the blood component collection device company, reported on Sunday fourth-quarter earnings of $17.8 million, or 69 cents a share, down from year-earlier earnings of $21 million, or 81 cents.

Energy company

Anadarko Petroleum

(APC) - Get Report

is expected by Wall Street analysts to post first-quarter profit of 83 cents a share on revenue of $3.42 billion.

Anadarko reports after the markets close Monday.

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-- Written by Joseph Woelfel

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Joseph Woelfel

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