NEW YORK --

Tiffany

(TIF) - Get Report

missed analysts' estimates on holiday profit as sales growth fell, hurt by declining sales in Europe and the U.S..

The luxury retailer's fourth-quarter net income fell 1.6% to $178.4 million, or $1.39 a share. Analysts had forecast $1.42 a share.

However, the retailer announced a higher-than-expected earnings forecast for the year. It expects profit of $4.05 a share for the year ending Jan 31, 2013. Analysts are looking for $3.92.

Tiffnay shares were up 3% to $70.75 in premarket trading Tuesday.

The fast food chain

Wendy's

(WEN) - Get Report

surpassed

Burger King

as the second biggest fast-food chain.

Wendy's total sales came in at $8.5 billion for 2011, higher than $8.4 billion for its competitor. However,

McDonald's

remains at the top, with sales of $34.2 billion.

The numbers are from food consulting firm Technomic.

Shares of Wendy's were up 1% to $5.08.

Adobe Systems

(ADBE) - Get Report

, a maker of digital media publishing and marketing applications, posted fiscal first quarter profit in line with analysts' estimates.

Adobe posted non-GAAP profit of $284.5 million, or 57 cents a share, on revenue of $1.045 billion. Analysts were expecting earnings of 57 cents a share on revenue of $1.053 billion.

For the fiscal second quarter ending in May, Adobe forecast non-GAAP earnings of 57 cents to 61 cents a share on revenue ranging from $1.09 billion to $1.14 billion. The current average analysts' view is for a profit of 60 cents a share on revenue of $1.10 billion.

Shares were down 3.9% to $33.15 in premarket trading.

AstraZeneca

(AZN) - Get Report

and

Targacept

(TRGT)

announced they will no longer go forward with plans to develop an experimental antidepressant following an unsuccessful late-stage clinical trial. The drug, called TC-5214, failed to show effectiveness compared to placebo when given to depressed patients.

Some analysts had cut their expectations for the drug, so the announcement was not a surprise. Still the drug was a lead product candidate for Targacept.

Shares of the company were plunging almost 13% to $6.40, while shares of AstraZeneca were down 1% to $44.95.

Amazon.com

(AMZN) - Get Report

agreed to acquire privately held

Kiva Systems

, a maker of robotic package handling systems for $775 million in cash.

Separately, Amazon will be selling $10 gift cards for $5 on Tuesday to people who visit AmazonLocal.com, its answer to deals sites such as

Groupon

and

LivingSocial

,

The Associated Press

reported.

Shares were down 0.7% to $184.18.

Goldman Sachs

(GS) - Get Report

has begun a new round of staff cuts in its trading and investment banking divisions,

Reuters

reported, citing three sources familiar with the matter..

Goldman eliminated 2,400 positions last year, and the sources said further reductions are possible as the company continues to reduce costs.

The investment bank's latest round of cuts is part of its annual employee review process.

Shares were off 0.6% to $123.50.

Oracle

(ORCL) - Get Report

, the database software giant, is expected by analysts Tuesday to earn 56 cents a share in its fiscal third quarter on revenue of $9.02 billion.

Wall Street will be looking to see if the massive expansion of Oracle's sales force that took place in the first half of the company's hiscal year has paid off in the third quarter. Shares were down 0.4% to $29.63.

Walt Disney

(DIS) - Get Report

said it expects to record an

operating loss of $200 million

in its fiscal second quarter ending in March stemming from the poor performance of the movie

John Carter

.

Shares were down 1% to $43.01.

-- Written by Joseph Woelfel and Chao Deng.

>To contact the writer of this article, click here:

Joseph Woelfel

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