Trading stocks that trigger major breakouts can lead to massive profits. Once a stock trends to a new high or takes out a prior overhead resistance point, then it's free to find new buyers and momentum players who can ultimately push the stock significantly higher.

Breakout candidates are something that I tweet about on a daily basis. I frequently tweet out high-probability setups, breakout plays and stocks that are acting technically bullish. These are the stocks that often go on to make monster moves to the upside. What's great about breakout trading is that you focus on trend, price and volume. You don't have to concern yourself with anything else. The charts do all the talking.

Trading breakouts is not a new game on Wall Street. This strategy has been mastered by legendary traders such as William O'Neal, Stan Weinstein and Nicolas Darvas. These pros know that once a stock starts to break out above past resistance levels and hold above those breakout prices, then it can easily trend significantly higher.

With that in mind, here's a look at five stocks that are setting up to break out and possibly trade higher from current levels.

Natural Health Trends

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One direct-selling and e-commerce player that's starting to spike within range of triggering a big breakout trade is Natural Health Trends (NHTC) - Get Report , which provides wellness, beauty and lifestyle products for consumers or business builders under the NHT Global brand name. This stock has been smacked lower by the bears over the last three months, with shares down sharply by 48.4%.

If you take a look at the chart for Natural Health Trends, you'll notice that this stock has been downtrending badly over the last month and change, with shares collapsing off its high of $50 to its recent low of $15.90 a share. During that downtrend, this stock has been consistently making lower highs and lower lows, which is bearish technical price action. That said, this stock has now started to reverse that downtrend in the short-term, and entered a new uptrend off that $15.90 low. That new uptrend is now quickly pushing shares of Natural Health Trends within range of triggering a big breakout trade above some key near-term overhead resistance levels.

Traders should now look for long-biased trades in Natural Health Trends if it manages to break out above Thursday's intraday high of $19.62 a share and then above more key resistance at $20 a share with high volume. Look for a sustained move or close above those levels with volume that hits near or above its three-month average action of 708,377 shares. If that breakout gets started soon, then this stock will set up to re-test or possibly take out its next major overhead resistance levels at around $22 to $24, or even $25 to $28 a share.

Traders can look to buy Natural Health Trends off weakness to anticipate that breakout and simply use a stop that sits right below some near-term support at $16.86 a share. One can also buy this stock off strength once it starts to clear those breakout levels with volume and then simply use a stop that sits a comfortable percentage from your entry point.

Argos Therapeutics

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A biopharmaceutical player that's starting to trend within range of triggering a big breakout trade is Argos Therapeutics (ARGS) , which focuses on the development and commercialization of personalized immunotherapies for the treatment of cancer and infectious diseases in North America. This stock has been annihilated by the sellers over the last three months, with shares off large by 59.3%.

If you take a glance at the chart for Argos Therapeutics, you'll notice that this stock spiked notably higher on Thursday right above some near-term support at $2 a share and back above its 20-day moving average of $2.28 a share with strong upside volume flows. Volume for that trading session registered just over 100,000 shares, which is well above its three-month average action of 69,594 shares. This high-volume rip to the upside is now quickly pushing shares of Argos Therapeutics within range of triggering a big breakout trade above some near-term overhead resistance levels.

Traders should now look for long-biased trades in Argos Therapeutics if it manages to break out above some near-term overhead resistance levels at $2.52 to $2.58 a share with high volume. Look for a sustained move or close above those levels with volume that hits near or above its three-month average action of 69,594 shares. If that breakout materializes soon, then this stock will set up to re-test or possibly take out its next major overhead resistance levels at its 50-day moving average of $2.98 to $3.17, or even $3.50 to $4 a share.

Traders can look to buy Argos Therapeutics off weakness to anticipate that breakout and simply use a stop that sits right below some near-term support at $2 a share. One could also buy this stock off strength once it starts to trend above those breakout levels with volume and then simply use a stop that sits a comfortable percentage from your entry point.

Heartware International

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Another medical device player that's starting to move within range of triggering a big breakout trade is Heartware International (HTWR) , which designs, develops, manufactures and markets miniaturized implantable heart pumps or ventricular assist devices for the treatment of advanced heart failure in the U.S., Germany and internationally. This stock has been destroyed by the bears over the last six months, with shares plunging lower by 61.3%.

If you take a glance at the chart for Heartware International, you'll see that this stock recently gapped-down sharply lower from around $45 a share to its new 52-week low of $25.01 a share with monster downside volume flows. Following that move, this stock has now started to uptrend off that $25.01 low, with shares moving sharply higher to its intraday high on Thursday of $33 a share. Shares of Heartware International broke out on Thursday above some near-term overhead resistance at $31.56 a share with strong upside volume flows. That high-volume breakout is now quickly pushing this stock within range of triggering a much bigger breakout trade above some key near-term overhead resistance levels.

Traders should now look for long-biased trades in Heartware International if it manages to break out above Thursday's intraday high of $33 a share and then above its recent gap-down-day high of $35 a share high volume. Look for a sustained move or close above those levels with volume that hits near or above its three-month average action of 483,471 shares. If that breakout develops soon, then this stock will set up to re-fill some of its recent gap-down-day zone that started near $45 a share.

Traders can look to buy Heartware International off weakness to anticipate that breakout and simply use a stop that sits right below some key near-term support levels at $30 a share or around $28.20 a share. One can also buy this stock off strength once it starts to bust above those breakout levels with volume and then simply use a stop that sits a comfortable percentage from your entry point.

Cross Timbers Royalty Trust

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Another investment management player that's starting to spike within range of triggering a near-term breakout trade is Cross Timbers Royalty Trust (CRT) - Get Report , which operates as an express trust in the U.S. This stock has been smacked lower by the sellers over the last three months, with shares off sharply by 28.3%.

If you take a glance at the chart for Cross Timbers Royalty Trust, you'll notice that this stock has been attempting to carve out a major bottoming chart pattern over the last month or so, after shares have found some buying interest multiple times at around $12 a share. This stock spiked notably higher on Thursday right off $12 a share with heavy upside volume flows. Volume for that trading session registered 253,00 shares, which is well above its three-month average volume of 31,079 shares. This high-volume rip to the upside is now quickly pushing Cross Timbers Royalty Trust within range of triggering a near-term breakout trade.

Traders should now look for long-biased trades in Cross Timbers Royalty Trust if it manages to break out above some near-term overhead resistance levels at $13 to $13.61 a share and then above $13.77 to its 50-day moving average of $13.89 a share with high volume. Look for a sustained move or close above those levels with volume that registers near or above its three-month average action of 31,079 shares. If that breakout fires off soon, then this stock will set up to re-test or possibly take out its next major overhead resistance levels at $14.50 to its 200-day moving average of $15.79, or even $16.40 to $17 a share.

Traders can look to buy Cross Timbers Royalty Trust off weakness to anticipate that breakout and simply use a stop that sits just below some key near-term support at $12 a share. One can also buy this stock off strength once it starts to clear those breakout levels with volume and then simply use a stop that sits a comfortable percentage from your entry point.

Synergy Resources

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My final breakout trading idea is energy player Synergy Resources (SYRG) , which  engages in the acquisition, development, exploitation, exploration, and production of oil and natural gas properties primarily located in the Denver-Julesburg Basin in Colorado. This stock has been under heavy selling pressure over the last three months, with shares down big by 41.9%.

If you look at the chart for Synergy Resources, you'll notice that this stock has been attempting to carve out a major bottoming chart pattern over the last few weeks, after shares found some buying interest at $5.05 to $5.18 a share. This stock exploded to the upside on Thursday by 6.9% right above those recent support levels with monster upside volume flows. Volume for that day registered 4.19 million shares, which is well above its three-month average action of 2.04 million shares. This high-volume jump higher is now quickly pushing shares of Synergy Resources within range of triggering a big breakout trade above some key near-term overhead resistance levels.

Traders should now look for long-biased trades in Synergy Resources if it manages to break out above Thursday's intraday high of $6.33 a share and then above more key near-term overhead resistance at $6.51 a share with volume that registers near or above its three-month average action of 2.04 million shares. If that breakout gets underway soon, then this stock will set up to re-test or possibly take out its next major overhead resistance levels at $7 to its 20-day moving average of $7.37, or even $8 to $8.50 a share.

Traders can look to buy shares of Synergy Resources off weakness to anticipate that breakout and simply use a stop that sits right below some key near-term support at $5.50 a share or around those recent double bottom support levels. One can also buy this stock off strength once it starts to trend above those breakout levels with volume and then simply use a stop that sits a conformable percentage from your entry point.

Disclosure: This article is commentary by an independent contributor. At the time of publication, the author held no positions in the stocks mentioned.