Moderna Phase One Covid Test Deemed a Success

Mish

A phase one Moderna test produced immune responses in all 45 test volunteers.

Please consider Moderna Phase 1 results show coronavirus vaccine safe, induces immune response.

The results released Tuesday involved three doses of the vaccine, tested in groups of 15 volunteers aged 18-55 who got two shots, 28 days apart. The groups tested 25, 100 or 250 micrograms of the vaccine.

Adverse events after the second dose occurred in seven of the 13 volunteers who got the 25-microgram dose, all 15 participants who received the 100 microgram dose and all 14 who got the 250 microgram dose. In the highest-dose group, three patients had severe reactions such as fever, chills, headache or nausea. One of these had a fever of 103.28 Fahrenheit (39.6 C).

“We didn’t see any events that are characterized as serious adverse events,” said lead author Dr Lisa Jackson of Kaiser Permanente Washington Health Research Institute in Seattle, referring to reactions that require hospitalization or result in death.

Moderna started has 2 tests in May. And will start Phase 3 tests with 30,000 volunteers on July 27.  

Best Wishes.

Mish

Comments (47)
CautiousObserver
CautiousObserver

Does anyone else view this as a case of "counting chickens before they are hatched?" This is Phase I trials. They established a dosage and got an immune response. Does that immune response prevent people from becoming sick and prevent them from becoming carriers that spread virus and will Moderna's vaccine candidate make it to a final product? Nobody knows.

Phase II: "Phase II trials further assess safety as well as if a drug works..."

Phase III: "Phase III trials compare a new drug to the standard-of-care drug. These trials assess the side effects of each drug and which drug works better..."

Lots of COVID-19 vaccines in the pipeline. None have been proven to prevent disease yet. Moderna up 35% in two days as though it is all a done deal that will be signed and delivered in the next 30 days. Crazy.

Realist
Realist

Funny. Rarely would phase 1 results get much notice, but since a successful vaccine would be a huge factor towards getting things back to normal, this becomes big news.

Success in phase 1 is fairly common, only to be undone in phase 2 or 3. Still, it's a plus that phase 1 was a success. Still a long way to go.

I continue expect to see multiple vaccines developed, each with varying levels of effectiveness, taken on an annual basis, beginning sometime in 2021.

PecuniaNonOlet
PecuniaNonOlet

Does a vaccine matter at this point? If people are getting re-infected after a few months then the vaccine is only going to last a quarter or two at best. Get vaccinated every 6 months?

Rbm
Rbm

Two things to watch.
Remember the money is in the treatment not a cure.
I feel between the ebola vac and this one. May lead to the industry to pushing congress to cut safety trials( ie cost) on future medicines. .

CaliforniaStan
CaliforniaStan

"In the highest-dose group, three patients had severe reactions such as fever, chills, headache or nausea. One of these had a fever of 103.28 Fahrenheit (39.6 C)." A vaccine with a high rate of reactions like this will not be well accepted.

anoop
anoop

hope!

Jackula
Jackula

Lots of questions...recent data seemingly shows second infections occurring in 3 months and worse than the first. Some sort of enhancement going on with the body's viral defenses? Recent data also shows antibodies fading quickly, in a few months at best. Having survived a moderate case of covid with mild after affects in no hurry to take the vaccine until proven out for a couple years on a few hundred million people.

Dodge Demon
Dodge Demon

If Powell and Mnunchin tipped the unemployed the night before every virus stock rumor was floated they could make more money in their Robinhood accounts then they would on unemployment or working. A perpetual motion wealth creation machine, as it seems to work every time. Pretty good for the Pharma C-Suiters, too!

IA Hawkeye in SoCal
IA Hawkeye in SoCal

You wont see any vaccine going into my body.

Montana33
Montana33

I have many friends who say they are afraid of taking a vaccine that was rushed to market and they would wait to see how it goes. I say, isn’t getting Covid worse? They say.... I may not get covid but if I get a shot then I know I will suffer the side effects that could be very bad. These are not anti vaxers. They all believe in vaccines in general. It’s bizarre but they think too many corners will be cut and any vaccine could be more dangerous than we know. I will be first in line for a vaccine but I wonder if I am the exception?

JCPatriot
JCPatriot

Vaccines sound great but in reality they aren't going to be anywhere near 100% effective. And since most on here probably don't realize that the rationale of using widespread vaccination depends a good deal on herd immunity, which they also don't believe in, we may be relying on hydroxychoroquine more. Oops, they don't believe in that either, despite the recent studies.

inonothing
inonothing

From yesterday’s NYTimes, “Moderna, Johnson & Johnson and the Oxford-AstraZeneca group have received a total of $2.2 billion in federal funding to support their vaccine programs.”


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