Human Genome Sciences (HGSI) was jumping 34 1/4, or 22%, to 188 1/4 on news that it received a U.S. patent on the CCR5 human gene which acts as an important entry point for the AIDS virus.

CheckFree Holdings

(CKFR)

is buying

TransPoint

for $1 billion in stock. TransPoint is an electronic billing and payment joint venture between

Microsoft

(MSFT) - Get Report

and

First Data

(FDC) - Get Report

.

Credit Suisse First Boston

reiterated its buy rating on CheckFree with a price target of 110.

CheckFree Holdings was soaring 44 7/8, or 67.9%, to 114 1/16; Microsoft was declining 3/16 to 98 5/8 and First Data was bouncing 1 1/4 to 49 1/2.

Mergers, acquisitions and joint ventures

Akamai

(AKAM) - Get Report

was bouncing 20 5/16, or 9.1%, to 242 3/8 after it said it is in an alliance to deploy its services within

America Online

(AOL)

. AOL was sliding 1 1/2 to 54 1/2.

Be Free

(BFRE)

was climbing 8 7/8, or 8.2%, to 117 after it said it will buy

Trivida

for 1.56 million shares or about $170 million.

Cisco

(CSCO) - Get Report

was slipping 1/8 to 127 13/16 after it said that it will acquire

Growth Networks

for $355 million.

Danaher

(DHR) - Get Report

will acquire

American Precision

(APR)

for about $250 million. Danaher said it would pay $19.25 a share in cash for American Precision. Danaher was unchanged at 41 3/16 and American Precision was popping 7 7/16, or 65%, to 18 7/8.

TheStreet.com Inc.

(TSCM)

, the publisher of this Web site, has hired

Wasserstein Perella

to explore strategic alternatives, including a potential sale of the company, the

Journal

reported, citing people familiar with the matter. The

Journal

reported that in recent days, TheStreet.com has been shopped to other Net companies, citing a person familiar with the matter, while another person said the company had been approached by a would-be acquirer. TheStreet.com confirmed that it has retained the services of Wasserstein Perella. TheStreet.com was mounting 7/8, or 5.4%, to 16 7/8.

Earnings/revenue reports and previews

(

Earnings estimates from First Call/Thomson Financial; earnings reported on a diluted basis unless otherwise specified.

)

Ace

(ACL)

was advancing 1 9/16, or 10.2%, to 16 3/4 after it posted fourth-quarter earnings excluding items of 52 cents a share, a penny ahead of the 16-analyst estimate but down from the year-ago operating earnings of 55 cents.

Analog Devices

(ADI) - Get Report

was climbing 3 15/16 to 123 11/16 after it reported first-quarter earnings of 50 cents a share, beating the 20-analyst estimate of 45 cents and the year-ago 18 cents a share. The company set a 2-for-1 stock split. The company said second-quarter revenues could total $535 million to $545 million and EPS in the range of 55 cents to 57 cents, above the 19-analyst estimate of 48 cents.

Applied Materials

(AMAT) - Get Report

was jumping 6 7/8 to 173 1/2 after it posted first-quarter earnings of 80 cents a share, beating the 28-analyst estimate of 77 cents and up from the year-ago 12 cents. The company also set a 2-for-1 stock split. First Boston raised its earnings estimates on Applied Materials and upped its price target to 225 from 185.

Deutsche Banc Alec. Brown

increased its earnings estimate and six-month price target on the stock, while

Bear Stearns

raised its earnings view and lifted its price target to 200 from 170.

CBRL Group

(CBRL) - Get Report

was advancing 11/16, or 7.6%, to 9 11/16 after it posted second-quarter earnings of 20 cents a share, a penny better than the 16-analyst estimate but down from the year-ago 28 cents.

Equitable Resources

(EQT) - Get Report

was skidding 5/16 to 34 3/16 after it posted fourth-quarter earnings of 79 cents, better than the 10-analyst estimate of 76 cents and the year-ago 11 cents.

Lycos

(LCOS)

was lifting 4 11/16, or 6.7%, to 73 3/4 after it reported second-quarter earnings last night of 3 cents a share, beating the 14-analyst estimate of a penny and up from the year-ago report of a 2-cent loss.

Modis Professional Services

(MPS)

was moving up 9/16 to 18 1/2 after it posted fourth-quarter earnings of 17 cents a share, a penny ahead of the 12-analyst estimate and up from the year-ago 9 cents a share.

SmithKline Beecham

(SBH) - Get Report

, which plans to merge with

Glaxo Wellcome

(GLX)

, reported 1999 pretax profit rose 13%, to $3.14 billion. Separately, Glaxo reported pretax profits for 1999 of about $4.4 billion. SmithKline Beecham was slipping 2 1/8 to 53 3/4 and Glaxo Wellcome was losing 2 3/16 to 46 1/2.

TD Waterhouse

(TWE)

was climbing 1 5/8, or 10.4%, to 17 1/4 after it posted first-quarter earnings of 17 cents a share, well above the nine-analyst estimate of 8 cents and the year-ago 9 cents. The company said the customer assets in the latest quarter rose 57% to more than $150 billion, while new account openings rose 56% to 260,000, before acquisitions from 167,000 account openings a year ago.

Viacom

(VIA) - Get Report

was shedding 2 3/4 to 56 1/2 after it said it reported fourth-quarter earnings of 19 cents a share, beating the 13-analyst estimate of 14 cents and up from the year-ago 15 cent-profit.

Offerings and stock actions

Ask Jeeves

(ASKJ)

was declining 3 9/16 to 78 15/16 after it said it filed for a $150 million stock offering. The company said $100 million would be sold by the company, while $50 million will come from shareholders.

CompuCredit

(CCRT)

was edging up 3/8 to 34 1/4 after it priced an offering of 4.6 million shares at $33.50 each.

Merrill Lynch

priced 3.65 million shares of

LendingTree

(TREE) - Get Report

at $12 each, the top of the estimated $10 to $12 range. The Charlotte, N.C.-based company allows consumers to compare and apply for various personal loans online. LendingTree was moving up 6 13/16, or 56.7%, to 18 13/16.

Analyst actions

Merrill Lynch

reinstated coverage of the major U.S. telecommunications companies today, three months after former analyst Dan Reingold departed for

Credit Suisse First Boston

in exchange for several wheelbarrows full of lucre. Analyst Adam Quinton reinstated coverage of:

  • AT&T (T) - Get Report, with a buy rating and price target of 70. AT&T was climbing 1 1/2 to 49 1/2;
  • BellSouth (BLS) , with a buy rating and a price target of 60. BellSouth was lifting 9/16 to 43 3/16;
  • SBC Communications (SBC) , with an intermediate and long-term buy rating and a 65 price target. SBC Communications was sliding 3/4 to 39 15/16;
  • Bell Atlantic (BEL) , with a buy rating and a 12-month price target of 80. Bell Atlantic was bouncing 3/4 to 55;
  • GTE (GTE) - Get Report, with a buy rating and a 12-month price target of 97. GTE was advancing 3/4 to 65 9/16;
  • Qwest Communications (Q) , with an intermediate-term accumulate rating, a long-term buy rating and a 12- to 18-month price target of 65. Qwest Communications was shedding 1 5/8 to 48 3/16;
  • MCI WorldCom (WCOM) , with an intermediate-term accumulate rating, a long-term buy rating and a 12- to 18-month price target of 75. MCI WorldCom was edging up 1/8 to 48;
  • Global Crossing (GBLX) , with an intermediate-term accumulate rating, a long-term buy rating and a price objective of 70. Global Crossing was losing 1 1/8 to 59 13/16;
  • Williams Communications (WCG) - Get Report, with an intermediate-term accumulate rating, a long-term buy rating and a 12- to 18-month price target of 55. William Communications was moving up 1 3/4 to 45 3/4; and
  • U S West (USW) , with an intermediate-term accumulate rating and a long-term buy rating. A 12- to 18-month price objective was placed on the stock of 112, which is based on its 65 target on Qwest -- with which U S West plans to merge -- multiplied by the fixed exchange ratio of 1.7293. U.S. West was skidding 3/16 to 75 1/4.

CSFB raised its price target on

ADC Telecommunications

(ADCT) - Get Report

to 50 from 40. ADC was popping 1 5/16 to 40 15/16.

First Boston downgraded

Abercrombie & Fitch

(ANF) - Get Report

to buy from strong buy and lowered its 12-month target price to 30 from 42.

Deutsche Banc Alex. Brown

downgraded Abercrombie to buy from strong buy. Abercrombie & Fitch was declining 3 7/8, or 19.8%, to 15 5/8.

Bear Stearns

cut

Agilent

(A) - Get Report

to attractive from buy, based on the price of the stock, but in an unusual move, boosted the target price to 90 from 80. Agilent was slipping 1 1/4 to 80 5/8.

J.P. Morgan started

Celgene

(CELG) - Get Report

as a buy. Celgene was soaring 19 11/16, or 17.3%, to 133 1/2.

Morgan Stanley Dean Witter

sliced its rating on

Coca-Cola Enterprises

(CCE)

to outperform from strong buy. The firm also reduced its position in the stock by 1%. Coca-Cola Enterprises was sliding 1 13/16, or 6.4%, to 26 1/8.

Bear Stearns started coverage of

Deere

(DE) - Get Report

with a buy rating and set a 55 price target on the stock. Deere was hopping 1/8 to 40 9/16.

J.P. Morgan upped

Everest Re

(RE) - Get Report

to buy from market performer. Everest Re was gaining 1 13/16, or 8%, to 24 1/4.

First Boston upgraded

Johnson & Johnson

(JNJ) - Get Report

to buy from hold. Johnson & Johnson was climbing 3/16 to 79 15/16.

Bear Stearns started coverage of

Network Appliance

(NTAP) - Get Report

with a buy rating and set a price target of 200 on the stock. Network Appliance was jumping 8 3/16, or 5.4%, to 159 3/4.

First Boston initiated coverage of

PurchasePro.com

(PPRO)

with a strong buy rating and placed a 12-month price target of 205 on the stock. PurchasePro.com was mounting 12 1/8, or 10%, to 131 1/2.

First Boston raised its earnings estimates and raised its near-term price target on

Razorfish

(RAZF)

to 75. Razorfish yesterday posted fourth-quarter earnings of 6 cents a share, a penny ahead of the 10-analyst estimate and up from the year ago 3 cents. Razorfish was shedding 5 3/4, or 11%, to 46 1/8.

Merrill reinstated coverage of

Reynolds Metals

(RLM) - Get Report

with an intermediate and long-term buy rating. Reynolds Metals was rising 1 1/16 to 70 1/2.

Salomon Smith Barney

upped its rating on

Weirton Steel

(WS)

to buy from neutral and raised its price target to 12 from 2. Weirton Steel was adding 7/8, or 10.6%, to 9 1/8.

Miscellany

Microsoft

(MSFT) - Get Report

has told lawmakers that any breakup of the company would be a "regulatory death sentence," the

Journal

reported. However, the software titan did signal that it would accept some "common sense" restrictions in an effort to settle the government's antitrust claims against it, the

Journal

reported.

Rite Aid

(RAD) - Get Report

was unchanged at 7 after it said it will restructure its corporate pharmacy department.

Thousands of tobacco farmers are expected to file suit in federal court today alleging tobacco companies have set out to negate a government-administered system designed to prop up prices for tobacco leaf, the

Journal

reported. The newspaper said the suit is expected to seek $69 billion in damages.

The Heard on the Street column in the

Journal

says the latest craze to sweep the daytrading world, is snapping up shares of companies that make "fuel cells," huge batteries capable of powering a house, or even a factory, for long periods without recharging. Mentioned among some stocks which have jumped as a result, are

Plug Power

(PLUG) - Get Report

,

FuelCell Energy

(FCL)

and

Astropower

(APWR)

.

Power Plug was sinking 6 3/8, or 5%, to 120; FuelCell Energy was climbing 2 3/4, or 5.2%, to 55 and Astropower was adding 1/2 to 23 1/8.