NEW YORK (

TheStreet

) - Some industries are simply poised to consolidate and there's money to be made on those prospects, whether it's banking in the 1990s, railroads in the 2000s or the current healthcare and wireless sectors.

When a recent bout of healthcare and wireless merger mania runs its course,

Glenview Capital Management

and

Paulson & Co.

are poised to emerge as the two hedge funds that best identified consolidation trends in both industries, and profited to the tune of billions of dollars.

As some stocks in both sectors surge amid a

frenzy of healthcare deals

and

wireless industry mergers

, the hedge funds had a clear rationale to stake billions on trades across both industries.

Tenet Healthcare's

(THC) - Get Report

Monday acquisition

of

Vanguard Health Systems

(VHS)

at a 70% premium, for instance, stands out as just the latest multi-billion dollar merger in a healthcare industry reshuffle, as providers brace for the impact of the

Affordable Care Act

(ACA), which was mostly upheld by the U.S. Supreme Court about a year ago.

Expecting a wave of consolidation as hospitals, outpatient facilities, healthcare providers and pharmacy benefit managers merge, Glenview has made the sector its biggest bet in a stock portfolio that exceeds $10 billion, according to

Bloomberg

data.

The fund's two top holdings are leveraged to the healthcare sector. Seven of the Larry Robbins-run Glenview top-10 holdings are in the healthcare space, which is expected to grow dramatically in the wake of ACA, commonly known as 'Obamacare.'

Life Technologies

(LIFE) - Get Report

is Glenview's biggest bet, helping the fund to a significant profit after the genetic sequencing machinery specialist was acquired by

Thermo Fisher Scientific

(TMO) - Get Report

. The deal comes as manufacturers such as Life Technologies and

Illumina

(ILMN) - Get Report

work to build lower-cost sequencing machines that can be used in individual cancer treatment.

Glenview's second-largest holding, hospital network

Health Management Associates

(HMA)

, has become subject to takeover speculation and is impacted by Monday's proposed merger between Tenet and Vanguard Health Systems. After Glenview took a near 15% stake in Health Management, the hedge fund rebuffed notions it would look to acquire the $4 billion acute care hospital network outright.

Instead, Health Management Associates may play into the hedge fund's expressed post-'Obamacare' expectation of healthcare industry consolidation. Glenview's stakes in

McKesson

(MCK) - Get Report

, Tenet,

Community Health Systems

(CYH) - Get Report

,

Humana

(HUM) - Get Report

and

HCA Holdings

(HCA) - Get Report

are the fund's other healthcare investments among its top-10 holdings. Glenview is also an investor in

Cigna

(CIG) - Get Report

,

Thermo Fisher Scientific

(TMO) - Get Report

,

Walgreens

(WAG)

and

Hospira

(HSP)

.

In 'Obamacare,' healthcare insurance coverage is expected to dramatically expand and impact states such as Texas that lag the nation in overall coverage. For hospital chains, the increase in coverage may mean an expansion into new markets, while it could also lead to a reduction in bad debt expense.

The legislation has sent ripples across the healthcare industry. Some estimate that between 16 million to 20 million new Americans will be eligible to enroll in Medicaid through 'Obamacare,' a change that's already prompted the

merger

of

WellPoint

(WLP)

and

Amerigroup

( AGP) and a

tie-up

between

Aetna

(AET)

and

Coventry Healthcare

( CVH).

Pharmacy benefit managers such as

Express Scripts

(ESRX)

,

CVS Caremark

(CVS) - Get Report

and Walgreens, meanwhile, have used mergers to expand their

networks

in anticipation of changes to the cost structure of prescription drug plans.

Glenview is positioned for further consolidation of the healthcare sector, as 'Obamacare' kicks in and impacts sector-wide earnings and strategy.

The fund's bet is most similar to one put on by John Paulson-run

Paulson & Co.

in the consolidating wireless industry, as also-ran carriers such as

Sprint

(S) - Get Report

,

T-Mobile

(TMUS) - Get Report

,

Leap Wireless

(LEAP)

,

Clearwire

(CLWR)

and

MetroPCS

seek strategic partners to grow their wireless subscribers and compete against

AT&T

(T) - Get Report

and

Verizon

(VZ) - Get Report

.

Given the shaky finances, bargain basement share prices and need to plow billions into network upgrades and handset subsidies among second-tier industry players, Paulson & Co. staked a

multi-billion dollar bet

on wireless industry consolidators.

Those bets have already paid off handsomely amid Sprint's

ongoing efforts

to buy all of Clearwire, and Japanese telecom

SoftBank's

near-complete

effort to buy Sprint.

Paulson & Co. has even had an influence on how the industry consolidates, after the $18 billion hedge fund gave

crucial support

to SoftBank's play for Sprint and T-Mobile's

acquisition of MetroPCS

, another top holding.

The fund, which made billions shorting the U.S. subprime housing market ahead of the financial crisis, could even be seen as adding a voice of temperance to wireless industry consolidation. Paulson & Co.

could have turned wireless M&A into a frenzy

given the number of vocal hedge funds investing in the sector.

Hedge funds such as Paulson & Co. are often celebrated for winning macroeconomic bets like a subprime short, or panned for trades such as a faltering investment in gold and gold miners.

Those trying to position ahead of industry trends would do well to also take notice when funds as large as Paulson and Glenview make trades across an entire sector such as wireless or healthcare.

Other investors as notable as Warren Buffett-run

Berkshire Hathaway

(BRK.A) - Get Report

, David Einhorn-run

Greenlight Capital Management

and Leon Cooperman-run

Omega Advisors

are also exposed to consolidation in either the healthcare or wireless sectors.

-- Written by Antoine Gara in New York

Follow @antoinegara