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Updated from 3:18 p.m. EDT

Stocks closed slightly lower Tuesday as a U.S.-led military coalition struck targets in Afghanistan for the third straight day.

Preliminary closing numbers showed the

Dow Jones Industrial Average

with a loss of 21.73 points, or 0.2%, at 9046.21, while the


was off 35.22 points, or 2.2%, at 1570.73. The

S&P 500

lost 5.51 points, or 0.5%, to 1056.93.

In London, the FTSE 100 lost 23 points, or 0.5%, to 5010, while Germany's DAX was down 19 points, or 0.4%, at 4477. Japan's Nikkei index fell 1.9% to 10,012. Hong Kong's Hang Seng rose 391, or 3.9%, to 10,359.

The United Nations said the bombing campaign in Afghanistan killed four of its workers stationed about two miles outside Kabul. The workers were involved in landmine removal.

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Meanwhile, Wall Street continued to resize amid a severe downturn in its underwriting business.

Credit Suisse First Boston

confirmed Tuesday it will cut 2,000 workers and record a $187 million loss in the third quarter, its first loss since 1997. The job cuts will reduce expenses by $1 billion. Shares of

Credit Suisse Group

( CSR), the parent company of CSFB, fell 2.1% to $32.85.

A venture that includes a unit of

Royal Dutch Petroleum

( RD) agreed to buy


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share of two U.S. refinery operations for about $2.4 billion. The venture will also assume about $1.4 billion of debt. Royal Dutch was up 18 cents to $51.37, and Texaco rose $1.73 to $70.06.

Around 4 p.m. EDT, the 10-year Treasury note was down 24/32 at 103 5/32 to yield 4.60%.