Starting in 2021, the budget airline will begin its first ever service in the lucrative trans-Atlantic market, the company announced.
The move will mean the airline will now need to battle head-to-head with massive U.S. rivals such as American Airlines Group (AAL) and equally formidable foreign carriers such as Air France-KLM (AFLYY) and British Airways.
"London is the largest metro area JetBlue doesn't yet serve from both Boston and New York, and we could not be more thrilled to be changing that in the years ahead," said President Joanna Geraghty in a statement.
The service is expected to use single-aisle Airbus aircraft with a "reimagined" version of its Mint business class service which currently offers lie-flat seats and separate suites to customers in the U.S.
The company said it was still evaluating which airports in London it will serve. The large airports include Heathrow, Gatwick, and Stanstead.
The stock rallied 3.6% Wednesday following reports that JetBlue would begin flying to London. Despite that, shares are still down 12.5% over the last year through Wednesday.