Revenue dropped by 15% quarter-to-quarter to 6.6 billion euros ($7.17 billion).
The firm reported a 2015 fourth quarter net loss of 2.1 billion euros and a full year net loss of 6.8 billion euros.
Expenses rose largely because of restructuring and severance charges and litigation charges of 1.2 billion euros for the quarter.
"In 2015 we made considerable progress on the implementation of our strategy. The much-needed decisions we took in the second half of the year contributed to a net loss for the fourth quarter and full year," Co-CEO John Cryan said in a statement.
"We are focused on 2016 and continue to work hard to clear up our legacy issues. Restructuring work and investment in our platform will continue throughout the year."
Additionally, the firm is not giving bonuses to its management board and is cutting bonuses across its workforce, Bloomberg reports.
Cryan feels "personally responsible" for the bank's first full-year loss since the financial crisis, he told reporters in Frankfurt and he hopes employees won't find bonus cuts to be "too demotivating," Bloomberg noted.
Separately, TheStreet Ratings Team has a "sell" rating with a score of D+ on the stock.
This is driven by some concerns, which should have a greater impact than any strengths, and could make it more difficult for investors to achieve positive results compared to most of the stocks covered by the team.
The company's weaknesses can be seen in multiple areas, such as its deteriorating net income, disappointing return on equity and generally disappointing historical performance in the stock itself.
Recently, TheStreet Ratings objectively rated this stock according to its "risk-adjusted" total return prospect over a 12-month investment horizon. Not based on the news in any given day, the rating may differ from Jim Cramer's view or that of this articles's author.
You can view the full analysis from the report here: DB