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Regardless what the Federal Reserve does, some companies have powerful trends to bolster their numbers, Jim Cramer told his Mad Money viewers Wednesday. Don't overthink it, Cramer added, just buy what's working.

Do companies like Twilio (TWLO) - Get Report , Acacia Communications (ACIA) - Get Report and RedHat (RHT) - Get Report need interest rates to make money? Cramer said absolutely not. He recommended them in last week's game plan, and all three have delivered as expected.

Cramer is also bullish on FedEx (FDX) - Get Report , the shipper that continues to extend its global reach. He is also upbeat on the quarter posted by KB Home (KBH) - Get Report , which saw an upswing in demand thanks to strong job growth and the easing of mortgage restrictions.

So you can curse the Fed and yell all you want for not raising interest rates, Cramer concluded, or you can buy companies like Adobe Systems (ADBE) - Get Report , which is doing just fine regardless.

Executive Decision: Mike McNamara

For his "Executive Decision" segment, Cramer sat down with Mike McNamara, CEO of Flex (FLEX) - Get Report , formerly known as Flextronics, the contract manufacturer that Cramer characterized as an "innovation factory" for its customers. Shares of Flex are up 20% so far in 2016.

At his company's new innovation hub in New York, McNamara said customers can see a demo of a connected home, complete with lights, doors, HVAC and cars all talking to one another. All of these technologies are made possible by Flex and its many partners. Many of the core technologies used by these products, he continued, are owned by Flex.

Flex is also looking towards the future with technologies for augmented and virtual reality, which will have wide ranging applications, McNamara said, from consumer to industrial and healthcare.

McNamara said Flex is a partner in many health tracking and wearable devices and is working with the Food and Drug Administratiohn to help usher in even more devices that will not only allow doctors to monitor patients but diagnose problems from that data.

Cramer said he's always liked Flex for its great buyback and cashflow, but the company also has lots of great technology and partnerships.

Long-Term Thinking

When is owning a stock for the "long term" just a cop-out for owning a loser? When is it time to admit the truth and cut your losses? Cramer said as a general rule he prefers to stick with his convictions, as long as the facts haven't changed.

When both Sprint (S) - Get Report and T-Mobile (TMUS) - Get Report were on the ropes, Cramer saw value, and over the years that value was realized at both companies. Sprint has $11 billion in liquidity and is growing, while T-Mobile has doubled its customer base in recent years. As long as the balance sheet is strong, companies have the ability to turn things around, Cramer said.

Now it's Walt Disney's (DIS) - Get Report turn in the doghouse. Many investors have given up on Disney now that the company's crown jewel, ESPN, is seeing slowing subscriber rates. But is that really all Disney has to offer?

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On the company's earnings call, management noted that attendance is strong at its parks and there are many hit films in the pipeline, including the Star Wars franchise. Disneyhas the rights to plenty of live sporting events, many of which have yet to be monetized.

So just like with Sprint and T-Mobile, Cramer said Disney's best days are not behind them and he'd be a buyer for the long term.

Executive Decision: Brent Saunders

In his second "Executive Decision" segment, Cramer also sat down with Brent Saunders, president and CEO of Allergan (AGN) - Get Report , the drugmaker and Action Alerts PLUS holding that just purchased Tobira Therapeutics (TBRA) for $1.7 billion.

Saunders said that Allergan didn't overpay for Tobira and the company's treatment for liver disease will meet a large unmet need if approved. He explained the mixed clinical trial results released in June were misinterpreted and the second endpoint, the one where the drug did well, is what is most important for patients. Saunders also noted that Allergan is only paying a small upfront payment to Tobira and the rest is all performance based.

Saunders also commented on his company's recently announced social contract with patients, which outlines their commitment to patients. He said that Allergan has already committed to single-digit price increases for its existing drugs and would be doing shareholders a great disservice by price gouging and having to testify before Congress.

A government takeover of healthcare is not what the industry needs, Saunders said. The industry needs self-regulation and self-discipline to do the right thing.

Lightning Round

In the Lightning Round, Cramer was bullish on Travelers Companies (TRV) - Get Report , Broadcom (AVGO) - Get Report , Weyerhaeuser (WY) - Get Report , Clovis Oncology (CLVS) - Get Report and Taser International (TASR) .

Cramer was bearish on Genworth Financial (GNW) - Get Report .

No Huddle Offense

In his "No Huddle Offense" segment, Cramer said he's always on the lookout for transformative takeovers, like Tech Data's (TECD) - Get Report purchase of the technology solutions business of Avnet (AVT) - Get Report , featured on last night's show.

Cramer said he's also excited about Tessera Technologies' (TSRA) purchase of DTS (DTSI) , makers of audio chip technology, for a 24% premium. Tessera's technology is already a part of 100 billion chips and the addition of DTS only accelerates their growth story in the growing Internet of Things.

To watch replays of Cramer's video segments, visit the Mad Money page on CNBC.

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At the time of publication, Cramer's Action Alerts PLUS had a position in AGN.