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Viewers may have taken a holiday break, but the Food and Drug Administration didn't, Jim Cramer said on Tuesday's "Mad Money" TV show.

That's why he said it's time to buy


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, which was anointed by the FDA with an approvable letter for Vivitrol, its treatment for alcoholism.

"It's as close to having approval without having approval as a drug can be," he said.

While it's not a totally new treatment, it doesn't have a lot of competition. And, said Cramer, because Americans are lazy and don't want to work to treat their bad habits, this drug could explode.

He told a caller that he likes new pharma better than old, also recommending


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Gilead Sciences

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Biogen Idec

TheStreet Recommends

(BIIB) - Get Biogen Inc. Report


In the world of sleep drugs, Cramer said that the game was over for



and its sleep disorder treatment Lunesta. Instead, said Cramer,

Neurocrine Biosciences

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will be the winner in the sleep drug wars when its sleep drug is approved in 2006.

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Cramer said that Neurocrine's treatment has posted top-notch results in clinical trials, and that it has a 200-person sales team behind it. No matter how good a drug is, it will do better when a company throws the necessary resources behind it. He recommended buying the stock before FDA approval was granted.

He told a caller that personalized medicine and genetics wasn't the game to be in, but that history shows FDA approval will boost a stock.

Remember the Titaniums

What will be the best-performing stock of 2006? Cramer said to find out, you have to look back to 2005.

The best-performing stock of 2005 was

Titanium Metals


, but he doesn't think it will repeat its performance in 2006.

But titanium the metal is a different story. It's the best natural resource out there, better than gold, Cramer said, because of its use in the aerospace cycle.


(BA) - Get Boeing Company Report

is too big and too widely held to be in the running for best-performing stock in 2006, he said, adding that it may beat the



That leaves us with

Allegheny Technologies

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as Cramer's pick for best-performing stock of 2006.

Cramer said the company should beat the market because it has titanium exposure as the metal enters a bull market due to demand from the aerospace cycle, and the company is expanding all along the titanium production chain.

Natural Gas Wonders

Cramer is always on the hunt for a good stock in Canada and he welcomed Ernie Sapieha, president and chief executive of

Compton Petroleum


, to the show.

Sapieha said that the company has a lot of drilling opportunities and that gas prices are really solid, which should support the company in 2006. But Cramer was unconvinced that the company was all that different from other small natural gas businesses, so gave the stock one thumb up.

He was more enthusiastic about

Intermagnetics General


, which topped its latest quarterly earnings estimates.

All the upside in the last quarter was driven by the medical side of the business.

But Cramer thinks the company's superpower division -- which transports superconductor materials with no resistance so there's no loss of energy -- will generate profits in the not-so-distant future.

To view Cramer's interview with Sapieha, click here.

Lightning Round

Cramer was bullish on


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E*Trade Financial

(ET) - Get Energy Transfer, L.P. Report



(AMTD) - Get TD Ameritrade Holding Corporation Report


Best Buy

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Allscripts Healthcare Solutions

(MDRX) - Get Allscripts Healthcare Solutions, Inc. Report



(SBUX) - Get Starbucks Corporation Report


Hudson City Bancorp



Freeport-McMoRan Copper & Gold

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Edward Lifesciences

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(GGG) - Get Graco Inc. Report



(GOOG) - Get Alphabet Inc. Class C Report


Allied Capital




(GLW) - Get Corning Inc Report


Shanda Interactive



Energy Conversion Devices



Advanced Micro Devices

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Cramer was bearish on


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Circuit City

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Quality Systems



Ultimate Software Group



Dow Chemical

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AU Optronics






Sirius Satellite Radio

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Martha Stewart Living Omnimedia




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For more of Cramer's insights during the Lightning Round, click here


Want more Cramer? Check out Jim's rules and commandments for investing from his latest book by

clicking here


As originally published, this story contained errors. Please see

Corrections and Clarifications.

At the time of publication, Cramer was long Ameritrade, Boeing, Cephalon and Motorola.

Jim Cramer, host of the CNBC television program "Mad Money," is a Markets Commentator for, Inc., and CNBC, and a director and co-founder of All opinions expressed by Mr. Cramer on "Mad Money" are his own and do not reflect the opinions of or its affiliates, or CNBC, NBC UNIVERSAL or their parent company or affiliates. Mr. Cramer's opinions are based upon information he considers to be reliable, but neither, nor CNBC, nor either of their affiliates and/or subsidiaries warrant its completeness or accuracy, and it should not be relied upon as such. Mr. Cramer's statements are based on his opinions at the time statements are made, and are subject to change without notice. No part of Mr. Cramer's compensation from CNBC or is related to the specific opinions expressed by him on "Mad Money."

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