Click here for an archive of Cramer's "Mad Money" recaps.

Viewers may have taken a holiday break, but the Food and Drug Administration didn't, Jim Cramer said on Tuesday's "Mad Money" TV show.

That's why he said it's time to buy

Alkermes

(ALKS) - Get Report

, which was anointed by the FDA with an approvable letter for Vivitrol, its treatment for alcoholism.

"It's as close to having approval without having approval as a drug can be," he said.

While it's not a totally new treatment, it doesn't have a lot of competition. And, said Cramer, because Americans are lazy and don't want to work to treat their bad habits, this drug could explode.

He told a caller that he likes new pharma better than old, also recommending

Amgen

(AMGN) - Get Report

,

Gilead Sciences

(GILD) - Get Report

and

Biogen Idec

(BIIB) - Get Report

.

In the world of sleep drugs, Cramer said that the game was over for

Sepracor

(SEPR)

and its sleep disorder treatment Lunesta. Instead, said Cramer,

Neurocrine Biosciences

(NBIX) - Get Report

will be the winner in the sleep drug wars when its sleep drug is approved in 2006.

Image placeholder title

Cramer said that Neurocrine's treatment has posted top-notch results in clinical trials, and that it has a 200-person sales team behind it. No matter how good a drug is, it will do better when a company throws the necessary resources behind it. He recommended buying the stock before FDA approval was granted.

He told a caller that personalized medicine and genetics wasn't the game to be in, but that history shows FDA approval will boost a stock.

Remember the Titaniums

What will be the best-performing stock of 2006? Cramer said to find out, you have to look back to 2005.

The best-performing stock of 2005 was

Titanium Metals

(TIE)

, but he doesn't think it will repeat its performance in 2006.

But titanium the metal is a different story. It's the best natural resource out there, better than gold, Cramer said, because of its use in the aerospace cycle.

Boeing

(BA) - Get Report

is too big and too widely held to be in the running for best-performing stock in 2006, he said, adding that it may beat the

Dow

.

That leaves us with

Allegheny Technologies

(ATI) - Get Report

as Cramer's pick for best-performing stock of 2006.

Cramer said the company should beat the market because it has titanium exposure as the metal enters a bull market due to demand from the aerospace cycle, and the company is expanding all along the titanium production chain.

Natural Gas Wonders

Cramer is always on the hunt for a good stock in Canada and he welcomed Ernie Sapieha, president and chief executive of

Compton Petroleum

(CMZ)

, to the show.

Sapieha said that the company has a lot of drilling opportunities and that gas prices are really solid, which should support the company in 2006. But Cramer was unconvinced that the company was all that different from other small natural gas businesses, so gave the stock one thumb up.

He was more enthusiastic about

Intermagnetics General

(IMGC)

, which topped its latest quarterly earnings estimates.

All the upside in the last quarter was driven by the medical side of the business.

But Cramer thinks the company's superpower division -- which transports superconductor materials with no resistance so there's no loss of energy -- will generate profits in the not-so-distant future.

To view Cramer's interview with Sapieha, click here.

Lightning Round

Cramer was bullish on

Apple

(AAPL) - Get Report

,

E*Trade Financial

(ET) - Get Report

,

Ameritrade

(AMTD) - Get Report

,

Best Buy

(BBY) - Get Report

,

Allscripts Healthcare Solutions

(MDRX) - Get Report

,

Starbucks

(SBUX) - Get Report

,

Hudson City Bancorp

(HCBK)

,

Freeport-McMoRan Copper & Gold

(FCX) - Get Report

,

Edward Lifesciences

(EW) - Get Report

,

Graco

(GGG) - Get Report

,

Google

(GOOG) - Get Report

,

Allied Capital

(ALD)

,

Corning

(GLW) - Get Report

,

Shanda Interactive

(SNDA)

,

Energy Conversion Devices

(ENER)

and

Advanced Micro Devices

(AMD) - Get Report

.

Cramer was bearish on

Symantec

(SYMC) - Get Report

,

Circuit City

(CC) - Get Report

,

Quality Systems

(QSII)

,

Ultimate Software Group

(ULTI)

,

Dow Chemical

(DOW) - Get Report

,

AU Optronics

(AUO)

,

Motorola

(MOT)

,

Sirius Satellite Radio

(SIRI) - Get Report

,

Gateway

(GTW)

,

Martha Stewart Living Omnimedia

(MSO)

MSOand

Diodes

(DIOD) - Get Report

.

For more of Cramer's insights during the Lightning Round, click here

.

Want more Cramer? Check out Jim's rules and commandments for investing from his latest book by

clicking here

.

As originally published, this story contained errors. Please see

Corrections and Clarifications.

At the time of publication, Cramer was long Ameritrade, Boeing, Cephalon and Motorola.

Jim Cramer, host of the CNBC television program "Mad Money," is a Markets Commentator for TheStreet.com, Inc., and CNBC, and a director and co-founder of TheStreet.com. All opinions expressed by Mr. Cramer on "Mad Money" are his own and do not reflect the opinions of TheStreet.com or its affiliates, or CNBC, NBC UNIVERSAL or their parent company or affiliates. Mr. Cramer's opinions are based upon information he considers to be reliable, but neither TheStreet.com, nor CNBC, nor either of their affiliates and/or subsidiaries warrant its completeness or accuracy, and it should not be relied upon as such. Mr. Cramer's statements are based on his opinions at the time statements are made, and are subject to change without notice. No part of Mr. Cramer's compensation from CNBC or TheStreet.com is related to the specific opinions expressed by him on "Mad Money."

None of the information contained in "Mad Money" constitutes a recommendation by Mr. Cramer, TheStreet.com or CNBC that any particular security, portfolio of securities, transaction, or investment strategy is suitable for any specific person. You must make your own independent decisions regarding any security, portfolio of securities, transaction, or investment strategy mentioned on the program. Mr. Cramer's past results are not necessarily indicative of future performance. Neither Mr. Cramer, nor TheStreet.com, nor CNBC guarantees any specific outcome or profit, and you should be aware of the real risk of loss in following any strategy or investments discussed on the program. The strategy or investments discussed may fluctuate in price or value and you may get back less than you invested. Before acting on any information contained in the program, you should consider whether it is suitable for your particular circumstances and strongly consider seeking advice from your own financial or investment adviser.

Some of the stocks mentioned by Mr. Cramer on "Mad Money" are held in Mr. Cramer's Action Alerts PLUS Portfolio. When that is the case, appropriate disclosure is made on the program and in the "Mad Money" recap available on TheStreet.com. The Action Alerts PLUS Portfolio contains all of Mr. Cramer's personal investments in publicly-traded equity securities only, and does not include any mutual fund holdings or other institutionally managed assets, private equity investments, or his holdings in TheStreet.com, Inc. Since March 2005, the Action Alerts PLUS Portfolio has been held by a Trust, the realized profits from which have been pledged to charity. Mr. Cramer retains full investment discretion with respect to all securities contained in the Trust. Mr. Cramer is subject to certain trading restrictions, and must hold all securities in the Action Alerts PLUS Portfolio for at least one month, and is not permitted to buy or sell any security he has spoken about on television or on his radio program for five days following the broadcast.