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Digital Angel

(DOC) - Get Physicians Realty Trust Report

and its majority shareholder

Applied Digital Solutions

( ADSX) were big small-cap winners on Wednesday. St. Paul, Minn.-based Digital Angel was granted a patent for its syringe-implantable glucose-sensing RFID microchip. Digital Angel surged 94 cents, or 37.5%, to $3.45, while Applied Digital Solutions was trading up 61 cents, or 36%, to $2.30.

PRA International

( PRAI) gained as the Reston, Va.-based contract research organization reported a drop in third-quarter income, but still beat Wall Street's estimates. The company earned $8.2 million, or 33 cents a share, down from $9.2 million, or 38 cents a share, a year ago. Excluding stock-option expenses, PRA International earned 38 cents a share. Revenue totaled $89.6 million. Analysts polled by Thomson First Call were expecting earnings of 29 cents a share on revenue of $80.5 million. Shares were trading up $2.63, or 10%, to $29.85.

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SeaBright Insurance

( SEAB) gained after the Seattle-based company beat third-quarter expectations. The company earned $9.1 million, or 44 cents a share, compared with $5.1 million, or 30 cents a share, a year ago. Revenue increased 19.2% to $52.8 million. Analysts were looking for earnings of 35 cents a share on revenue of $51 million. Shares were rising $1.74, or 12.7%, to $15.50.

Integral Systems

( ISYS) tumbled after the Lanham, Md.-based satellite-systems company said that since efforts to sell the company have not resulted in any proposal, agreement or transaction, it will explore other strategic alternatives while continuing to evaluate a possible sale. The company also said that fiscal 2007 revenue and EPS are expected to be at least 20% and 10%, respectively, greater than the prior year. Shares were trading down $3.70, or 11.7%, to $27.90.

Seacoast Banking Corp. of Florida

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lost ground after the Stuart, Fla.-based firm missed analysts' third-quarter earnings expectations. The company posted income of $5.9 million, or 31 cents a share, compared with $5.6 million, or 32 cents a share, a year ago. Wall Street was looking for earnings of 38 cents a share. Shares fell $3.72, or 12.7%, to $25.50.