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) -- Myriad Genetics'

(MYGN) - Get Myriad Genetics, Inc. Report

monopoly on genetic testing for breast cancer risk has been torn down by the U.S. Supreme Court's ruling on human gene patents Thursday. One day later, Wall Street analysts are reacting accordingly.

With Myriad's patents on the BRCA1 and BRCA2 genes now invalidated, other companies like

Quest Diagnostics

(DGX) - Get Quest Diagnostics Incorporated Report


Bio-Reference Labs


are moving quickly to launch competitive tests for breast and ovarian cancer risk.

Myriad shares actually surged higher within minutes of yesterday's Supreme Court decision on the belief that the company's core gene-testing business would not be adversely affected, at least immediately. But that Wall Street insta-analysis turned out to be incorrect and by the end of Thursday trading, Myriad shares were in the red, down 6% to $32.01.

On Friday, analysts followed up with Myriad downgrades and cuts to price targets:

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Credit Suisse's Vamil Divan:

A mixed ruling by the Supreme Court of the United States (SCOTUS) in the Myriad gene patent case was generally in-line with our expectations. What was surprising to us, however, was the speed with which competitors announced that they would be entering the BRCA testing market, in spite of SCOTUS upholding that cDNA is patent eligible. While the near-term MYGN story is still solid, the longer-term concerns that we have had around the name are now accelerated as these competitors will likely cause MYGN to face pricing pressure and/or market share losses over time.

RBC Capital's Michael Yee:

Our bullish MYGN thesis has played out and risk/reward is less favorable at current levels: the company has met or beat estimates 9 quarters in a row and the Supreme Court case overhang played out in line with our expectations (cDNA upheld but isolated DNA was rejected). Going forward at current levels, 6-12 mo visibility remains more challenging because: 1) 3 competitors including Quest, BRLI, DNATraits, Ambry, announcedthey plan to launch a new BRCA test which was sooner than consensus expectations and casts uncertainty on real impact to estimates (MYGN is likely to sue them for Sanger sequencing and/or infringing cDNA patents upheld today but this requires resources and time), 2) it is now unclear how much market share these new competitors may garner but there's new risk of possible downside earnings revisions if even 5% market share loss occurs over next year ($20M)...

It's worth noting that Yee, on Thursday, defended Myriad and said the Court's ruling would have no impact on its gene-testing business.

Some analysts are defending Myiad, like Cantor Fitzgerald's Sung Ji Nam:

Despite SCOTUS' only partial reversal of the Federal Circuit decision, twocompetitors (BRLI and DGX) announced their intentions to provide BRCA1/2testing by year-end, which is currently exclusively offered by MYGN in the U.S. Webelieve that MYGN's IP around BRACAnalysis remains strong through 2018, givenfour of the nine patent claims adjudicated by SCOTUS have been essentially upheldand MYGN's large majority of the patents and claims (~500 claims associated with24 patents, specifically primers, probes and method-of-use) remain unchallenged,and as such, we think MYGN will aggressively defend its IP going forward. Basedon our adjusted estimates (competition still entering in FY:14, higher SG&A fromlegal expenses, slightly slower share erosion vs. our prior estimates), we reiterateour BUY rating and raise our PT to $41 from $40.

-- Reported by Adam Feuerstein in Boston.

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Adam Feuerstein writes regularly for TheStreet. In keeping with company editorial policy, he doesn't own or short individual stocks, although he owns stock in TheStreet. He also doesn't invest in hedge funds or other private investment partnerships. Feuerstein appreciates your feedback;

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