Updated from 12:07 p.m. EDT

Millennium Pharmaceuticals

(MLNM)

saw heavy volume Tuesday after the company touted results from a phase III trial on its bone cancer drug.

The drug, Velcade, produced statistically

significant life extension in patients with relapsed multiple myeloma when compared with an existing treatment, said Millennium, which codevelops the drug with

Johnson & Johnson

(JNJ) - Get Report

. Millennium says the final survival analysis will be presented at the upcoming meeting of the American Society of Clinical Oncology in New Orleans on June 6. Shares of Millennium traded up 93 cents, or 6.9%, to $14.49. Roughly 14.5 million shares traded.

More than 14 million shares of

Home Depot

(HD) - Get Report

traded after the company reported a big increase in first-quarter earnings and revenue, and guided both lines up for the full year. Home Depot cited improvement in both individual transactions and sales per square foot in its release. Shares of Home Depot were recently trading up $1.15 cents, or 3.4%, to $34.62.

TXU

(TXU)

was sharply higher in solid volume after it raised full-year earnings guidance, outlined a reorganization of its business structure and agreed to a 10-year technology outsourcing agreement with a French firm.

The Dallas power producer forecast 2004 earnings from continuing operations of $3.82 to $4.32 a share, well above the $3.04 a share analysts estimated. The company realigned itself into three main divisions consisting of its utility operations plus the unregulated TXU Energy and TXU Power, and named heads of each. The stock traded up $3.40, or 9.8%, to $38.05, with about 13.5 million shares traded.

In addition to Home Depot and TXU,

NYSE

high-volume leaders included

Nortel

(NT)

,

Lucent

(LU)

and

General Electric

(GE) - Get Report

.

Adding to Millennium Pharmaceuticals,

Nasdaq

companies on the high-volume list included

Intel

(INTC) - Get Report

,

Microsoft

(MSFT) - Get Report

,

Cisco

(CSCO) - Get Report

and

Sun Microsystems

(SUNW) - Get Report

.

Looking at Nasdaq price movers,

Aspen Technology

(AZPN) - Get Report

rose after the company announced that Statoil, a Norweigian oil and gas producer, signed a multiyear license agreement.

Under the deal, Aspen will provide software that Statoil will use in an effort to create more efficient engineering work processes and for new exploration and production projects. Financial terms were not disclosed. Shares of Aspen traded up 78 cents, or 13.9%, to $6.38.

Shares of

Neose Technologies

(NTEC) - Get Report

rose after the company announced plans to raise $33.85 million in a stock offering. The company is selling shares for $6.77 each to existing shareholders, new shareholders and several executive officers. Shares of Neose traded up 80 cents, or 11.8%, to $7.59.

Collectors Universe

(CLCT) - Get Report

rose after it reported third-quarter earnings from continuing operations of 13 cents a share on revenue of $6.9 million. In the year-ago period, Collectors reported a loss of 1 cent a share on revenue of $5.2 million. Shares of the company traded up $1.05, or 11.3%, to $10.38.

Shares of

Westell Technologies

(WSTL) - Get Report

fell ahead of the company's fourth-quarter earnings announcement. Right before the market closed, Westell delivered earnings of 9 cents a share on revenue of $62.1 million.

Analysts were looking for earnings of 9 cents a share on revenue of $61.3 million.

Looking ahead, Westell says it expects first-quarter earnings of 8 cents a share on revenue of $56 million to $58 million. Analysts, meanwhile, are looking for the company to earn 9 cents a share on revenue of $62.55 million. Shares of Westell traded down 27 cents, or 4.8%, to $5.41 during the regular session and after hours were recently trading down 21 cents, or 3.9%, to $5.20.

Micromuse Shares Brood

Micromuse

(MUSEE)

fell after the company said it earned 4 cents a share in the second quarter and predicted earnings of 4 cents to 6 cents in the third quarter. The company also forecast third-quarter revenue or $38 million to $40 million. Analysts were looking for earnings of 5 cents a share on revenue of $40 million in the third quarter. Shares of Micromuse traded down 82 cents, or 12%, to $6.01.

Over on the Big Board,

Celltech

(CLL)

shares rose after the company agreed to be acquired by UCB for $19.44 a share, or about $2.7 billion. UCB said that the prospects of complementary product offerings, strengthened research and development and that stronger and broader commercial operations made CLL an attractive target. Shares of Celltech traded up $3.57, or 23.2%, to $18.98.

Several Indian firms rebounded Tuesday after selling off on Monday. Shares of

HDFC Bank

(HDB) - Get Report

rebounded and traded up $3.24, or 14.1%, to $26.18.

Videsh Sanchar

(VSL) - Get Report

traded up 77 cents, or 13.9%, to $6.31. And shares of

Satyam Computer Services

(SAY)

traded up $1.67, or 10%, to $18.45.

Worries about India's new political makeup -- after India's national government was ousted last week -- pressured the firms Monday, but news that Congress Party leader Sonia Gandhi decided not to accept her new position as prime minister, sparked a rally in Indian stocks on Tuesday.

Jo-Ann Stores

(JAS)

rose after the company reported first-quarter earnings results and raised fiscal 2005 earnings guidance. During the first quarter it earned 30 cents a share on revenue of $404.9 million. Looking ahead, the company said that it expects to report a loss of 2 cents to 7 cents a share during the second quarter, traditionally a seasonally weak period. Analysts are looking for the company to lose 6 cents a share.

Additionally, Jo-Ann said that it expects to earn $2.20 to $2.25 in fiscal 2005, which is up modestly from the $2.18 to $2.22 it had previously forecast. Analysts are looking for the company to earn $2.19. Shares of Jo-Ann Stores traded up $3, or 12.3%, to $27.35.

Shares of

Bisys Group

(BSG)

sank after the company said it would restate several years' worth of financial results. Bisys, which previously said that it would incur an adjustment of $24.7 million in its life-insurance division, upped that amount to $70 million to $80 million on Monday.

The adjustment was made as part of a continuing review and analysis of commissions receivable in its life insurance division. The restatement, the company said, will not affect its fourth-quarter earnings estimates of 16 cents to 18 cents a share. Shares of Bisys traded down $1.13, or 8%, to $12.97.

Tsakos Energy Navigation

(TNP) - Get Report

slumped after the company announced it sold 2.5 million shares for $70 million, or about $28 a share. Shares were sold pursuant to a pre-existing shelf offering dated Dec. 15, 2003. Shares of Tsakos traded down $1.80, or 5.9%, to $28.75.