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Shares of Portola Pharmaceuticals (PTLA) - Get Portola Pharmaceuticals, Inc. Report were up 4%, to $29.65, in premarket trading Friday. The South San Francisco, Calif.-based company has inked a $150 million royalty pact with HealthCare Royalty Partners for the development and commercialization of andexanet alfa, a potential antidote for Factor Xa inhibitors.

Portola received $50 million at the transaction's close and could receive an additional $100 million upon U.S. Food and Drug Administration approval of AndexXa (andexanet alfa) in exchange for a tiered, mid-single-digit royalty based on global sales of the agent.

The agreement with HealthCare Royalty Partners is subject to total royalty payments of up to 195% of the $150 million funded by HCR, at which point the agreement would expire.

In August, Portola received a complete response letter from the FDA regarding its application for andexanet alfa. The company said it expects to resubmit the application within the first half of 2017.

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Other biotech stock movers on Friday morning include Esperion Therapeutics (ESPR) - Get Esperion Therapeutics, Inc. Report , up 10% to $14, and Medicines (MDCO) - Get Medicines Company Report , up 9% to $41.50.