Shares of

Exact Sciences

(EXAS) - Get Report

rose nearly 50% after the Marlborough, Mass., genomics company said improvements to its technology demonstrated sensitivity in excess of 80% for detecting colorectal cancer in a recent research study. Exact Sciences was surging $1.28, or 49.4%, to $3.87.

Genzyme

( GENZ) dropped after the Cambridge, Mass., biotech company said its fourth-quarter sales would miss analysts' expectations. Genzyme said revenue will be $722 million in the quarter, up from $591 million a year earlier. Analysts surveyed by Thomson First Call were expecting revenue of $729.9 million. Shares of Genzyme were down $1.90, or 2.5%, to $73.14.

DJ Orthopedics

( DJO) moved higher after the Vista, Calif., medical-supply company said fourth-quarter sales were about $75 million, up 10% from a year ago. Shares of DJ Orthopedics were gaining $2.19, or 7.7%, to $30.80.

Accentia Biopharmaceuticals

(ABPI)

jumped after the Tampa, Fla., company said data from a Phase 2 clinical trial of BiovaxID, its lymphoma vaccine, were encouraging. Shares of Accentia were gaining $1.47, or 27.5%, or $6.82.

CryoLife

(CRY) - Get Report

rose after the Kennesaw, Ga., company, which provides tissues for transplants, raised its 2006 sales guidance. The company said it expects this year's sales to range from $74 million to $77 million, an increase from the previous estimate of $72 million to $76 million. CryoLife was up 89 cents, or 28.7%, to $3.99 in recent trading.