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Shares of

Exact Sciences

(EXAS) - Get Exact Sciences Corporation Report

rose nearly 50% after the Marlborough, Mass., genomics company said improvements to its technology demonstrated sensitivity in excess of 80% for detecting colorectal cancer in a recent research study. Exact Sciences was surging $1.28, or 49.4%, to $3.87.

Genzyme

( GENZ) dropped after the Cambridge, Mass., biotech company said its fourth-quarter sales would miss analysts' expectations. Genzyme said revenue will be $722 million in the quarter, up from $591 million a year earlier. Analysts surveyed by Thomson First Call were expecting revenue of $729.9 million. Shares of Genzyme were down $1.90, or 2.5%, to $73.14.

DJ Orthopedics

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( DJO) moved higher after the Vista, Calif., medical-supply company said fourth-quarter sales were about $75 million, up 10% from a year ago. Shares of DJ Orthopedics were gaining $2.19, or 7.7%, to $30.80.

Accentia Biopharmaceuticals

(ABPI)

jumped after the Tampa, Fla., company said data from a Phase 2 clinical trial of BiovaxID, its lymphoma vaccine, were encouraging. Shares of Accentia were gaining $1.47, or 27.5%, or $6.82.

CryoLife

(CRY) - Get CryoLife, Inc. Report

rose after the Kennesaw, Ga., company, which provides tissues for transplants, raised its 2006 sales guidance. The company said it expects this year's sales to range from $74 million to $77 million, an increase from the previous estimate of $72 million to $76 million. CryoLife was up 89 cents, or 28.7%, to $3.99 in recent trading.