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Updated from 2:54 p.m.

Shares of

Advancis Pharmaceutical

(AVNC)

were among the worst-performing health and pharmaceutical stocks Tuesday, tumbling 62.2% after the company announced the termination of its

GlaxoSmithKline

(GSK) - Get GlaxoSmithKline Plc Report

collaboration.

The pharmaceutical company said that GlaxoSmithKline served the company notice that it would discontinue its collaboration effective Dec. 15. To date, Advancis has received an upfront, non-refundable $5 million payment and a subsequent non-refundable milestone payment of $3 million, which was recognized during the fourth quarter of 2003. Advancis expects to recognize another $3.5 million in deferred revenue during the fourth quarter of 2004.

In addition to announcing the termination of its relationship with Glaxo, Advancis posted a third-quarter loss of 41 cents a share on sales of $3.1 million. Analysts polled by Thomson First Call were expecting a loss of 47 cents a share on sales of $4.9 million. Shares traded down $4.53 to $2.75.

UnumProvident

(UNM) - Get Unum Group Report

fell 9.8% after the disability insurance provider said it received additional subpoenas from the New York attorney general's office relating to compensation agreements between the company and insurance brokers. In June, the company disclosed that it received a similar subpoena from the New York attorney general relating to broker compensation and commission rates. The company said it continues to cooperate and that it would continue to provide any information requested. Shares traded down $1.33 to $12.19.

Shares of

Decode Genetics

(DCGN)

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rose 11.4% after the company said that results from its phase IIa clinical trial of a heart-attack drug it is working on showed promising results. The results showed that the drug suppressed production of leukotriene B4, the product of the branch of the leukotriene pathway that Decode's research has linked to increased risk of heart attack. Decode's drug, DG031, was originally developed by

Bayer

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. Decode acquired the rights to it in November 2003. Shares traded up 75 cents to $7.36.

Boston Scientific

(BSX) - Get Boston Scientific Corporation Report

fell 7% after the company posted strong third-quarter financial results but warned that fourth-quarter earnings could come in at the low end of the company's earnings guidance. During the third quarter, the medical-device maker earned 47 cents a share on sales of $1.48 billion. Analysts polled by Thomson First Call were expecting earnings of 46 cents a share on sales of $1.45 billion. Looking ahead, the company said that it would meet fourth-quarter earnings guidance of 48 cents to 51 cents a share, but that analysts should focus on the low end of the range. Analysts had been expecting earnings of 51 cents a share. Shares traded down $2.66 to $35.15.

Other health care volume movers included

UnitedHealth Group

(UNH) - Get UnitedHealth Group Incorporated Report

, down $6.85 to $66.50;

Pfizer

(PFE) - Get Pfizer Inc. Report

, unchanged at $29;

Merck

(MRK) - Get Merck & Co., Inc. Report

, up 26 cents to $31.16;

Anthem

(ATH) - Get Athene Holding Ltd. Class A Report

, down $7.30 to $73.70; and

Amgen

(AMGN) - Get Amgen Inc. Report

, up 1 cent to $56.64.