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) --The biotech sector proved once again in 2011 that picking the right stocks to own (or trade) produced outsized profits.

Eleven biotech stocks more than doubled their value this year, producing returns well in excess of the 7% performance of the Nasdaq Biotechnology Index. The S&P 500 is down 3% this year.

Here are the

five biggest drug-stock winners of 2011


No. 5:



Investors who clued into the potential of Pharmacyclics' experimental B-cell lymphoma drug PCI-32765 last year were rewarded big time this year when

Johnson & Johnson

(JNJ) - Get Johnson & Johnson Report

paid handsomely to secure licensing rights to the drug in December.

The stock: Pharmacyclics is up 140% this year through Dec. 16. The stock's performance this year, particularly two strong runs in the spring and late fall, illustrate how investors love to buy biotech stocks ahead of big drug research meetings.

No. 4:

TheStreet Recommends

Questcor Pharmaceuticals


Once again, selling a high-priced drug to relatively small groups of patients proves to be a winning formula for Questcor. Sales of H.P. Acthar Gel are surging and so are Questcor's profit.

The stock: This is the second consecutive year that Questcor lands on the list of best-performing biopharmaceutical stocks. Questcor shares are 197% since Dec. 16. Earnings are expected to double this year over 2010 and grow another 60% in 2012.

No. 3:



One day, Medivation shares are up 9% for the year. Twenty-four hours later, Medivation is up 162%. This sudden and spectacular jump in market value -- akin to winning the lottery -- is what makes biotech stocks irresistible for so many investors. Medivation's spark was the November announcement of a successful phase III study for its prostate cancer drug MDV3100.

The stock: Medivation shares weren't done moving higher after that very good, early November day. As of Dec. 16, Medivation is up 199% for the year.

No. 2:



It's fitting that the two top-performing biopharmaceutical stocks of 2011 are both focused on developing new drugs for hepatitis C. It's also telling that Inhibitex, clocking in at No. 2 this year, is still years away from (possibly) pushing a drug across the finish line and making it to the market.

The stock: Inhibitex shares are up 302% as of Dec. 16.

No. 1:



No surprise, right? Pharmasset's $11 billion ($137-per-share) takeover by

Gilead Sciences

(GILD) - Get Gilead Sciences, Inc. Report

last month was just icing on Pharmasset's very sweet year. The company's experimental pill PSI-7977, with its potential to eliminate the need for weekly interferon injections from hepatitis C therapy, could soon dominate a $20 billion treatment market.

The stock: Pharmasset shares rose a stunning 468% this year, as of Dec. 16.

>>To see these stocks in action, visit the

Five Drug Stock Winners of 2011

portfolio on Stockpickr.

--Written by Adam Feuerstein in Boston.

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Adam Feuerstein writes regularly for TheStreet. In keeping with company editorial policy, he doesn't own or short individual stocks, although he owns stock in TheStreet. He also doesn't invest in hedge funds or other private investment partnerships. Feuerstein appreciates your feedback;

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