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Cell Therapeutics


said preliminary data from a study of Xyotax in combination with carboplatin produced a major tumor response in 98% of first-line ovarian cancer patients.

The biopharmaceutical company said the phase II study was for first-line induction and single-agent maintenance therapy of advanced stage III/IV ovarian cancer. The data were reported at the annual meeting of the American Society of Clinical Oncology.

Of the 82 patients studied, 80 patients, or 98%, achieved a major tumor response during the induction phase of the therapy, including 85% with complete response and 12% with partial response.

Some side effects of the treatment included neuropathy, nausea, vomiting, febrile neutropenia and anemia.

Separately, Cell Therapeutics reported initial data from a phase I study of weekly Xyotax given in combination with radiation for patients with esophageal and gastric cancer. Of the 11 patients with loco-regional disease that could be evaluated for tumor response, four patients achieved a complete disappearance of their tumor and five patients achieved a 50% or greater shrinkage of their cancer.