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Professional traders running mutual funds and hedge funds don't just look at a stock's price moves, they track big changes in volume activity. Often, when above-average volume moves into a stock, it precedes a large spike in volatility.

Major moves in volume can signal unusual activity, such as insider buying or selling--or buying or selling by "superinvestors." These types of traders like to get in well before a bigger trend, so it's always a smart move to monitor unusual volume activity.

With that in mind, let's take a look at several stocks that are experiencing unusual volume activity.

Puma Biotechnology

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  • Wednesday's Volume: 2.55 million
  • Three-Month Average Volume: 938,000
  • Volume % Change: 169%

From a technical perspective, Puma Biotechnology (PBYI) - Get Puma Biotechnology, Inc. Report spiked sharply higher right above its 50-day at $34.55 and back above its 20-day at $36.55 with strong volume. This high-volume spike is quickly pushing this stock within range of triggering a big breakout trade.

Traders should look for long-biased trades in Puma Biotechnology as long as it's trending above its 20-day at $36.55 and then once it sustains a move or close above resistance levels at $41.35 to its 200-day at $43.32 and then over $43.20 with volume near or above 938,00 shares. If that breakout hits soon, then this stock will set up to re-test or possibly take out its next resistance levels at $47.45 to $50, or even $53.75 a share.

AeroVironment

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  • Wednesdays Volume: 678,000
  • Three-Month Average Volume: 132,190
  • Volume % Change: 469%

From a technical perspective, AeroVironment (AVAV) - Get AeroVironment, Inc. Report trended up back above its 50-day and 200-day moving averages with heavy volume. This high-volume jump higher is quickly pushing shares of AeroVironment within range of triggering a near-term breakout trade.

Traders should look for long-biased trades in AeroVironment as long as it's trending above its 50-day at $26.40 and then once it breaks out above some near-term resistance at $28.19 with volume near or above 132,190 shares. If that breakout triggers soon, then this stock will set up to re-test or possibly take out its next major resistance levels at $29.42 to $30.08, or even its 52-week high of $32.44 a share.

TripAdvisor

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  • Wednesday's Volume: 7.54 million
  • Three-Month Average Volume: 2.73 million
  • Volume % Change: 178%

From a technical perspective, TripAdvisor (TRIP) - Get TripAdvisor, Inc. Report spiked sharply higher off oversold levels with large upside volume. Market players should look for a continuation move higher in the short-term if this stock holds its recent upward price momentum.

Traders should look for long-biased trades in TripAdvisor as long as it's trending above support at $42 and then once it sustains a move or close above Wednesday's intraday high of $44.06 with volume near or above 2.73 million shares. If that move gets underway soon, then this stock will set up to re-test or possibly take out its next overhead resistance levels at its 20-day of $46.01 to $47, or even its 50-day at $48.89 a share.

DBV Technologies

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  • Wednesday's Volume: 207,000
  • Three-Month Average Volume: 74,695
  • Volume % Change: 167%

From a technical perspective, DBV Technologies (DBVT) - Get DBV Technologies SA Report spiked up right off its 20-day at $35.53 with above-average volume. This high-volume move is quickly pushing this stock within range of triggering a major breakout trade.

Traders should look for long-biased trades in DBV Technologies as long as it's trending above its 20-day at $35.53 or its 50-day at $34.96 and then once it sustains a move or close above some resistance at $37.50 to $37.75 and over its 52-week high of $37.98 with volume near or above 74,695 shares. If that breakout develops soon, then this stock will set up to re-test or possibly take out its next resistance levels at $40 to $42, or even $43 to $44.76 a share.

YY

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  • Wednesday's Volume: 2.38 million
  • Three-Month Average Volume: 749,223
  • Volume % Change: 254%

From a technical perspective, YY (YY) - Get JOYY Inc. Report jumped higher on Wednesday right off its 20-day at $45.45 with strong upside volume flows. This high-volume spike is quickly pushing shares of YY within range of triggering a big breakout.

Traders should look for long-biased trades in YY as long as it's trending above its 20-day at $45.45 or above its 200-day at $44.68 and then once it sustains a move or close above resistance at $48 to $49.90 with volume near or above 749,223 shares. If that breakout triggers soon, then this stock will set up to re-test or possibly take out its next resistance levels at $51 to $53, or even $55 to $55.50 a share.

Cytokinetics

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  • Wednesday's Volume: 1.13 million
  • Three-Month Average Volume: 319,445
  • Volume % Change: 307%

From a technical perspective, Cytokinetics (CYTK) - Get Cytokinetics, Incorporated Report ripped up and broke out above some near-term resistance at $12.05 with strong upside volume flows. Market players should look for a continuation move higher in the short-term if this recent uptrend for Cytokinetics remains intact.

Traders should look for long-biased trades in Cytokinetics as long as it's trending above $12 or above its 50-day at $11.38 and then once it sustains a move or close above Wednesday's intraday high of $12.55 with volume near or above 319,445 shares. If that move gets underway soon, then this stock will set up to re-test or possibly take out its next resistance levels at $13.20 to its 52-week high of $13.45, or even $14.30 a share.

Global Blood Therapeutics

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  • Wednesday's Volume: 14.13 million
  • Three-Month Average Volume: 1.19 million
  • Volume % Change: 1284%

From a technical perspective, Global Blood Therapeutics (GBT) - Get Global Blood Therapeutics Inc Report exploded higher on Wednesday with monster upside volume. Market players should look for a continuation move higher in the short-term if this stock remains in a strong uptrend.

Traders should look for long-biased trades in Global Blood Therapeutics as long as it's trending above its previous breakout level of $31 and then once it sustains a move or close above its 52-week high of $37.45 with volume near or above 1.19 million shares. If that move starts soon, then this stock will set up to re-test or possibly take out its next resistance levels at $40 to $45 a share.

This article is commentary by an independent contributor. At the time of publication, the author held no positions in the stocks mentioned.