Editor's Note: In this feature from Stockpickr, we highlight lists of stocks that have made new highs, lows or seen other unusual activity.

52-Week Highs

:

Nuveen Investments

( JNC) on Wednesday agreed to be acquired by a private-equity group led by Madison Dearborn Partners, sparking a 17% rise. The $5.4 billion deal sent the Chicago-based investment manager soaring $8.98 to a 52-week high of $63.14.

Biggest % Gainers

:

Fuel Tech

(FTEK) - Get Report

jumped 18% after landing a deal with a Hong Kong-based

Itochu

subsidiary. The two companies will work together on Fuel Tech's Fuel Chem program. The Illinois-based engineering company climbed $5.28 to $33.97.

Rising on Unusual Volume

: Trading at six times average volume,

Chart Industries

(GTLS) - Get Report

rose 9% after Ole Slorer upgraded the company to buy from neutral, noting the "industry will improve and expects shares to rise 54% over the next year." Chart Industries makes equipment used to produce and store gases. Shares increased $2.24 to $26.97.

Biggest % Losers

: After an interim analysis determined

Coley Pharmaceutical's

( COLY) lung cancer treatment to be ineffective and not worthy of continuation,

Pfizer

(PFE) - Get Report

, which licensed the drug to Coley, discontinued the program. The news sent Coley shares crashing down 59% to $3.46.

52-Week Lows

: Coley Pharmaceutical also finished Wednesday trading at a 52-week low.

Stocks with Unusual Option Activity

:

Motorola

( MOT) was experiencing unusual options activity Wednesday.

Latest Activist Situations

: In an amended 13D filing on

PHH

(PHH)

, 7.8% shareholder Pennant Capital disclosed a letter to the board of directors reiterating its strong objections to a sale at this time and also outlined several material omissions from the preliminary proxy statement filed June 18. PHH shares barely moved, increasing 2 cents to $31.10.

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