Editor's note: In this feature from Stockpickr, we highlight lists of stocks that have made new highs, lows or seen other unusual activity.

Biggest % Gainers

:

Data Domain

( DDUP), which provides data backup and disaster-recovery systems, rocketed 66% in its first day of trading Wednesday. The 7.4 million shares priced at $15 apiece and gained $9.95 on the day, closing at $24.95.

52-Week Highs

: Small-cap health-care diagnostics company

SurModics

(SRDX) - Get Report

shot up 19% Wednesday, after it announced a lucrative partnership with

Merck

(MRK) - Get Report

. The deal to produce eye-disease drugs states Merck will lead and fund development and commercialization and SurModics will manufacture and supply clinical and commercial products. SurModics rose $7.21 to a 52-Week high of $44.57.

Rising on Unusual Volume

: Trading nearly 10 times its average volume,

Spectrum Control

(SPEC)

climbed 18% after the maker of electronic products posted larger-than-expected second-quarter earnings and boosted guidance. Shares rose $2.47 to $16.34.

Biggest % Losers

: Shares of

Impac Mortgage

(IMH) - Get Report

plunged 22% Wednesday, after the company announced it won't declare a second-quarter dividend. Impac said it made the decision following higher-than-expected losses from accelerating liquidation of its real-estate-owned portfolio via an auction process. The Irvine, Calif. mortgage investment company's shares were down $1.27 to $4.59.

52-Week Lows

:

Aspreva Pharmaceuticals

( ASPV) dropped 10% to a 52-week low after a study showed its drug CellCept failed to treat a type of lupus significantly better than traditional intravenous treatment. The Canadian drug developer was down $1.90 to $17.13.

Latest Activist Situations

: In a 13D filing on

Sonesta International Hotels

( SNSTA), Mercury Real Estate Advisors disclosed a 9.4% stake in the company. The firm also disclosed a letter to Sonesta applauding the company's move to hire Goldman Sachs to explore strategic options. The stock slid 27 cents to $17.13.

Forum of the Day

akod opens discussion on

Blackstone's

(BX) - Get Report

House Of Pain

.

Do You Know the Answer?

Any opinions on

Garmin

(GRMN) - Get Report

,

Trapper81 asks.

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