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Dynavax Technologies'

(DVAX) - Get Dynavax Technologies Corporation Report

shares plummeted Monday after the company said clinical trial conditions made it impossible to tell whether its ragweed allergy treatment worked.

The company said that results from the trial were not clinically significant and efficacy measures were substantially lower in the latest trial than what has been observed in prior trials. Shares sank 24.5% to $6.45.

Shares of drug developer

BioCryst Pharmaceuticals

(BCRX) - Get BioCryst Pharmaceuticals, Inc. Report

fell 3.8% to $11.36 after the company appointed Jon Stonehouse its new chief executive. Founder and former CEO Dr. Charles Bugg retired.

St. Jude Medical

(STJ)

surged 6.1% to $37.12 early Monday after guiding higher on fourth-quarter sales.

The medical-device maker said it expects to meet analysts' estimates of 39 cents a share for the fourth quarter and sales should come in at $864 million, above the expected $843 million. Defibrillator sales should come in on the high end of the company's estimates, while sales of its atrial fibrillation, neuromodulation, cardiology and cardiac surgery products should exceed expectations, the company says.

Medical technology company

Affymetrix

(AFFX)

said it expects fourth-quarter revenue to reach $100 million, compared with $99.47 million expected by analysts surveyed by Thomson First Call. Shares gained 16.3% to $25.27.

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Shares of

Seattle Genetics

(SGEN) - Get Seagen, Inc. (SGEN) Report

jumped 21.7% to $6.44 after the company announced a license agreement with biotech giant

Genentech

( DNA) to develop a blood cancer drug dubbed SGN-40. The treatment is proposed for patients with multiple myeloma, chronic lymphocytic leukemia and non-Hodgkin's lymphoma.

Human Genome Sciences

( HGSI) gained 2% to $12.55 after the company said its 2006 results should be in line with prior guidance and revenue is expected to increase by about 50% from 2006 to 2007.

Among other health stock winners Monday were

The Medicines Co.

(MDCO) - Get Medicines Company Report

, up 1.2% to $32.61;

Cephalon

( CEPH), rising 2% to $71.16;

DepoMed

(DEPO)

, gaining 2.5% to $3.70;

Savient Pharmaceuticals

(SVNT)

, jumping 9% to $12.71; and

Oscient Pharmaceuticals

(OSCI)

, up 3.8% to $5.26.

Among the losers were

Pfizer

(PFE) - Get Pfizer Inc. Report

, off 1.2% to $25.99;

AstraZeneca

(AZN) - Get Astrazeneca PLC Sponsored ADR Report

, down 2.3% to $54.25;

GlaxoSmithKline

(GSK) - Get GlaxoSmithKline plc Sponsored ADR Report

, 2.3% lower to $52.74;

Targeted Genetics

(TGEN) - Get Tecogen Inc. Report

, sinking 10.8% to $4.83; and

Novogen

(NVGN)

, down 2.7% to $11.27.