David Fairhurst, global chief people officer, left the company, according to an internal memo from new CEO Chris Kempczinski, who is replacing ousted former CEO Steve Easterbrook.
Easterbrook was fired after the board's finding that "he violated company policy and demonstrated poor judgment involving a recent consensual relationship with an employee." McDonald's said it has a longstanding policy barring employees from relationships with direct or indirect reports.
McDonald's was cut to neutral from overweight at Piper Jaffray following the firing of Easterbrook and the price target was lowered to $195 from $224.
Fairhurst had been with the fast food restaurant chain since 2005, and was promoted to the top HR job shortly after Easterbrook was named CEO in 2015. Previously he had been McDonald's chief people officer for its European business.
Mason Smoot, a senior vice president who oversees strategic alignment and staff, will take Fairhurst's place on an interim basis.
McDonald's has been experiencing labor relations problems, according to a report from Bloomberg. Groups such as Fight for $15 and the American Civil Liberties Union said the company has tolerated workplace harassment and ignored safety issues. They also alleged McDonald's has failed to prevent misconduct including groping, inappropriate comments from supervisors and retaliation for speaking up.
Fairhurst and Easterbrook join McDonald's global Chief Marketing Officer Silvia Lagnado and Chief Communications Officer Robert Gibbs, both of whom left last month.
Shares were down 3.2% to $187.83 in trading Monday.