Updated from 2:21 p.m. EDT

Medical-device makers were among the best health care performers of Friday's session.

Stryker

(SYK) - Get Report

, which fell on Thursday despite beating first-quarter earnings targets, today closed up 1.2% to $67.

Boston Scientific

(BSX) - Get Report

added 2.3%, and

Medtronic

(MDT) - Get Report

gained 1.2%.

Avanir Pharmaceuticals

(AVNR)

continued its recent march higher. Avanir has soared about 265% this week. On Wednesday, the company said it saw positive results from a late-stage clinical trial for diabetic neuropathic pain drug Zenvia. Avanir closed up 50 cents, or 12.8%, to $4.40.

Monogram Biosciences

( MGRM) was also riding momentum. Thomas Weisel Partners, which began coverage of the stock recently with a rating of market weight, said Monogram's revenue will continue to climb into 2008. The stock, which is up 23% for the week, closed up 23 cents, or 11.1%, to $2.31.

The Nasdaq Biotechnology Index, of which both Avanir and Monogram are components, was higher by only 0.6%. The Amex Pharmaceutical Index was up 0.5%, despite a number of components losing ground.

Shares of

Merck

(MRK) - Get Report

were 2.7% higher after Prudential upped its stock price target for the drugmaker to $55 from $48.

But rival

Schering-Plough

( SGP) slid after both AG Edwards and HSBC Securities downgraded the stock. Schering-Plough was down 29 cents, or 0.9%, to $30.71.

Also among losers,

Pfizer

(PFE) - Get Report

said its most-recent quarter was better than expected, but the drugmaker took down its full-year forecast for profits, the low end of which would be more than 10 cents short of what Wall Street wanted to see. Pfizer was off 0.4% to $26.97.

Other pharmaceutical companies were mixed.

AstraZeneca

(AZN) - Get Report

was up 1.1%,

Bristol-Myers Squibb

(BMY) - Get Report

was up 0.9%, and

Eli Lilly

(LLY) - Get Report

gained 0.9%.

Elsewhere,

Amgen

(AMGN) - Get Report

was down 0.6%,

Teva Pharmaceutical

(TEVA) - Get Report

was down 0.9%, and

Wyeth

( WYE) was up 0.3%.