The Washington, D.C-based company said it posted net earnings of $746.8 million, or $1.05 a share, in the fourth quarter, down from $856.6 million, or $1.21 a share, a year earlier.
On an adjusted basis, the company posted per-share earnings of $1.28, above Zacks consensus estimates of $1.27 and the $1.19 it earned a year ago. Revenue increased 5.5% year over year to $5.4 billion vs. $5.09 billion in the year-earlier period.
"We are very pleased with our fourth-quarter results, which wrapped up a tremendous 2018," Danaher CEO Thomas Joyce said in a statement. "We believe we gained share in many of our businesses, driven by a combination of new product innovation and enhanced commercial execution."
The stock fell 0.7% to close at $105.27 on Tuesday.
For the full year, Danaher earned $2.7 billion, or $3.74 a share. On an adjusted basis, the company posted net earnings per share of $4.52 vs. $4.03 in 2017.
For the first quarter of 2019, Danaher said it expects earnings per share in the range of 78 cents to 81 cents, and non-GAAP adjusted earnings per share in the range of $1.00 to $1.03.
For the full year 2019, the company anticipates earnings per share in the range of $3.85 to $3.95, and non-GAAP adjusted profit of $4.75 to $4.85 a share.
Danaher is a global science and technology conglomerate that operates more than 20 underlying companies.