Per-share earnings reached $1.96, up 5.4% from $1.86 in the year-earlier quarter. Shares outstanding dropped 13% to 148.1 million. Revenue rose 1.1% to $842 million.
A survey of analysts by FactSet was looking for profit of $1.90 a share on revenue of $833 million.
Net interest income, the difference between what a bank takes in on loans and pays out on deposits, fell 2.1% to $586 million.
The net interest margin narrowed 8 basis points to 3.52%. FactSet's survey was looking for a margin of 3.5%.
Comerica shares are trading down 0.9% at $66.37.