DELAFIELD, Wis. (Stockpickr) -- At Stockpickr, we track daily portfolios of stocks that are the biggest percentage gainers and the biggest percentage losers.

Stocks that are making large moves like these are favorites among short-term traders because they can jump into these names and try to capture some of that massive volatility. Stocks that are making big-percentage moves either up or down are usually in play because their sector is becoming attractive or they have a major fundamental catalyst such as a recent earnings release. Sometimes stocks making big moves have been hit with an analyst upgrade or an analyst downgrade.

Regardless of the reason behind it, when a stock makes a large-percentage move, it is often just the start of a new major trend -- a trend that can lead to huge profits. If you time your trade correctly, combining technical indicators with fundamental trends, discipline and sound money management, you will be well on your way to investment success.

With that in mind, let's take a closer look at a several stocks under $10 that are making large moves to the upside.

PharmAthene

PharmAthene (PIP) , a biodefense company, develops and commercializes medical countermeasures against biological and chemical threats in the U.S. This stock closed up 4% to $1.79 in Thursday's trading session.

Thursday's Range: $1.75-$1.82
52-Week Range: $1.19-$2.59
Thursday's Volume: 503,000
Three-Month Average Volume: 458,251

From a technical perspective, PIP bounced sharply higher here right off its 200-day moving average of $1.73 with above-average volume. The relative strength in shares of PIP on Thursday is now quickly pushing the stock within range of triggering a near-term breakout trade. That trade will hit if PIP manages to take out its 50-day moving average of $1.89 to its gap-down-day high from September at $2 with high volume.

Traders should now look for long-biased trades in PIP as long as it's trending above its 200-day at $1.73 or above more near-term support at $1.61 and then once it sustains a move or close above those breakout levels with volume that hits near or above 458,251 shares. If that breakout develops soon, then PIP will set up to re-fill some of its previous gap-down-day zone that started near $2.30. Any high-volume move above $2.30 will then give PIP a chance to re-test or possibly take out its 52-week high of $2.59.

Sophiris Bio

Sophiris Bio (SPHS) - Get Report , a clinical-stage biopharmaceutical company, focuses on the research, development, and commercialization of products for the treatment of urological diseases. This stock closed up 10.9% to $3.25 in Thursday's trading session.

Thursday's Range: $2.76-$3.25
52-Week Range: $2.10-$5.18
Thursday's Volume: 19,000
Three-Month Average Volume: 25,572

From a technical perspective, SPHS jumped sharply higher here right above some near-term support at $2.77 with lighter-than-average volume. This sharp move to the upside on Thursday also pushed shares of SPHS back above both its 50-day moving average at $2.93 and its 200-day moving average of $3.23. It also pushed shares of SPHS into breakout territory, since the stock took out some near-term overhead resistance levels at $3.01 to $3.04. Shares of SPHS are now quickly moving within range of triggering another breakout trade. That trade will hit if SPHS manages to clear Thursday's intraday high of $3.25 to some more key overhead resistance levels at $3.34 to $3.60 with high volume.

Traders should now look for long-biased trades in SPHS as long as it's trending above its 50-day at $2.93 or above more near-term support at $2.77 and then once it sustains a move or close above those breakout levels with volume that hits near or above 25,572 shares. If that breakout hits soon, then SPHS will set up to re-test or possibly take out its next major overhead resistance levels at $4 to $4.25, or even its 52-week high at $5.18.

MEI Pharma

MEI Pharma (MEIP) - Get Report , an oncology company, focuses on the clinical development of novel therapies for the treatment of cancer. This stock closed up 0.69% to $7.25 a share in Thursday's trading session.

Thursday's Range: $7.07-$7.48
52-Week Range: $5.51-$13.98
Thursday's Volume: 56,000
Three-Month Average Volume: 63,839

From a technical perspective, MEIP trended modestly higher here right above its 50-day moving average of $6.91 with decent upside volume flows. This stock has been uptrending for the last three months and change, with shares moving higher from its low of $5.51 to its recent high of $7.56. During that uptrend, shares of MEIP have been making mostly higher lows and higher highs, which is bullish technical price action. This spike to the upside and relative strength on Thursday is now starting to push shares of MEIP within range of triggering a big breakout trade. That trade will hit if MEIP manages to take out some key near-term overhead resistance levels at $7.56 to its 200-day moving average of $7.68 with high volume.

Traders should now look for long-biased trades in MEIP as long as it's trending above its 50-day at $6.91 or above more key near-term support at $6.61 and then once it sustains a move or close above those breakout levels with volume that hits near or above 63,839 shares. If that breakout develops soon, then MEIP will set up to re-test or possibly take out its next major overhead resistance levels at $8.55 to $9.40, or even $10.

To see more stocks that are making notable moves higher, check out the Stocks Under $10 Moving Higher portfolio on Stockpickr.

-- Written by Roberto Pedone in Delafield, Wis.

RELATED LINKS:

>>5 Stocks Insiders Love Right Now

>>Beat the S&P With 5 Hated Short-Squeeze Stocks

>>3 Stocks Spiking on Big Volume

Follow Stockpickr on Twitter and become a fan on Facebook.

At the time of publication, author had no positions in stocks mentioned. Roberto Pedone, based out of Delafield, Wis., is an independent trader who focuses on technical analysis for small- and large-cap stocks, options, futures, commodities and currencies. Roberto studied international business at the Milwaukee School of Engineering, and he spent a year overseas studying business in Lubeck, Germany. His work has appeared on financial outlets including CNBC.com and Forbes.com. You can follow Pedone on Twitter at www.twitter.com/zerosum24 or @zerosum24.