DELAFIELD, Wis. ( Stockpickr) -- Trading stocks that trigger major breakouts can lead to massive profits. Once a stock trends to a new high, or takes out a prior overhead resistance point, then it's free to find new buyers and momentum players that can ultimately push the stock significantly higher.>>5 Stocks Under $10 Set to Soar One example of a successful breakout trade I flagged recently was biopharmaceutical player Coronado Biosciences (CNDO), which I featured in Dec. 9's " 5 Stocks Poised for Breakouts" at $1.74 share. I mentioned in that piece that shares of CNDO had started to uptrend recently off its low of $1.25 a share, after gapping down huge from $7 a share in October. That uptrend was quickly pushing shares of CNDO within range of triggering a major breakout trade above some near-term overhead resistance levels at $1.86 to $1.88 a share, and then above more key resistance levels at $1.91 to its gap-down-day high of $2.16 a share. Guess what happened? Shares of CNDO started to flirt with that breakout the same day my article was published, after the stock hit an intraday high on Dec. 9 of $1.95 a share. This stock continued to flirt with breakout territory on Dec. 10, after it hit an intraday high of $2.01 a share. Share of CNDO stop the flirting this morning as the stock took out all of those overhead resistance levels with massive upside volume. At last check, CNDO has tagged an intraday high today of $2.70 a share, which represents a monster gain of over 50% in a very short timeframe. As you can see here, CNDO made a huge move after it busted higher into its large gap down zone with heavy upside volume. >>5 Big Trades for Year-End Gains Breakout candidates are something that I tweet about on a daily basis. I frequently tweet out high-probability setups, breakout plays and stocks that are acting technically bullish. These are the stocks that often go on to make monster moves to the upside. What's great about breakout trading is that you focus on trend, price and volume. You don't have to concern yourself with anything else. The charts do all the talking. Trading breakouts is not a new game on Wall Street. This strategy has been mastered by legendary traders such as William O'Neal, Stan Weinstein and Nicolas Darvas. These pros know that once a stock starts to break out above past resistance levels, and hold above those breakout prices, then it can easily trend significantly higher. >>3 Stocks Rising on Unusual Volume With that in mind, here's a look at five stocks that are setting up to break out and trade higher from current levels.