Is It Safe? Pipeline Pain at AstraZeneca

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AstraZeneca's(AZN Quote) best-known drugs -- Nexium, Crestor and Seroquel -- generated 48% of its revenue in the first quarter. But in a few years, the company won't be able to rely on these money-makers.

The drugmaker will lose the patents on these heavy hitters by 2014, leaving a hole in AstraZeneca's lineup that will need to be plugged if the company expects to maintain, let alone increase, its revenue.

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