Orexigen Starts New Trial of Obesity Drug

Orexigen Therapeutics(OREX Quote) climbed 13% after the biopharmaceutical company initiated the second study in a phase III clinical trial for its lead product candidate, Contrave.

Contrave, a treatment for obesity, uses the central nervous system to effect weight loss. In a prior phase IIb trial, Contrave -- a combination of Bupropion SR and Naltrexone SR -- demonstrated a statistically significant weight loss at 48 weeks compared with other drugs alone and the placebo, Orexigen said.

In April, the San Diego, Calif., company initiated enrollment in its first phase III clinical trial, which is designed to evaluate the treatment alone or when combined with intense diet, exercise and behavior modification. ...