Thursday's Early Winners & Losers

Aspen Technology(AZPN Quote) tumbled after the Cambridge, Mass., software and services company said it will have to restate results due to stock option errors. The company estimated that additional compensation and related payroll tax expenses need to be recorded in fiscal years 2002, 2003, 2004, 2005 and the first three quarters of fiscal 2006. Aspen Technology also reported fourth-quarter revenue of $79.2 million, up 10% from a year ago. For fiscal 2006, AspenTech reported revenue of $293.3 million, up 9% from a year ago. Also, Bradley T. Miller was named senior vice president and chief financial officer, effective Sept. 19. Shares were slipping 5.8% to $10.84.

Dynavax Technologies (DVAX Quote) gained on news that the Berkeley, Calif., drug manufacturer entered into a research collaboration and license agreement with AstraZeneca (AZN Quote). The pact will cover therapies for the treatment of asthma and chronic obstructive pulmonary disease. Shares were climbing 10.7% to $4.65.

Martek Biosciences (MATK Quote) plummeted after the Columbia, Md., company, which makes nutritional oils and dietary supplements, offered a weak forecast. For the fourth quarter, the company said it expects revenue of $63 million to $66 million and earnings of 9 cents to 12 cents a share. Wall Street is looking for revenue of $74.8 million and earnings of 20 cents a share. Martek was trading down 16.3% to $23.90. ...