This Day On The Street
Continue to site right-arrow
This account is pending registration confirmation. Please click on the link within the confirmation email previously sent you to complete registration.
Need a new registration confirmation email? Click here
Stocks Under $10 with 50-100% upside potential - 14 days FREE!

CureVac Signs An Exclusive License Agreement With Sanofi Pasteur To Develop And Commercialize An MRNA-based Prophylactic Vaccine

Stocks in this article: SAN SNY

TUBINGEN, Germany, July 1, 2014 /PRNewswire/ -- CureVac, a German clinical-stage biopharmaceutical company, today announced the execution of an exclusive license agreement with Sanofi Pasteur S.A., the vaccines division of Sanofi (EURONEXT: SAN and NYSE: SNY), to develop and commercialize an mRNA-based vaccine against an undisclosed pathogen.

In 2011, CureVac and Sanofi Pasteur signed a collaboration and license option agreement for several pre-defined pathogens. CureVac met all pre-agreed milestones and acceptance criteria relating to these agreements, and therefore Sanofi Pasteur exercised its first option and extended its exclusive and non-exclusive options on all five pathogens.

Under the commercial license agreement, Sanofi Pasteur will fund all research, development, manufacturing and commercialization activities and will have exclusive worldwide marketing rights for the RNActive ® vaccine. CureVac will receive an undisclosed upfront payment from Sanofi Pasteur for the option exercise and an additional payment for extending the option term for the other pathogens.

In addition, CureVac is eligible for additional milestone payments up to €150.5 million for achieving several clinical, regulatory and commercial milestones, as well as royalty payments associated with products sales of RNActive ® vaccines.

"Sanofi Pasteur's basic objective of finding new vaccine solutions to address patients' needs is furthered by our collaboration with CureVac," comments Nicolas Burdin, Head of Discovery Research at Sanofi Pasteur in France. "Accessing CureVac's innovative mRNA technology may allow Sanofi Pasteur to exploit a platform that can be more broadly applicable across indications to develop vaccines, as the RNActive ® technology is expected to complement conventional technologies."

"We are very pleased that our RNActive ® technology platform has reached all significant milestones in this important collaboration with Sanofi Pasteur, the largest company entirely dedicated to vaccines," says Ingmar Hoerr, CEO of CureVac. "Our mRNA-based approach shows significant advantages for the development of vaccines, particularly for infectious diseases, such as thermostability and low cost of goods after up-scaling."

The exclusive license agreement for the development and commercialization of an mRNA-based vaccine is also a result of the positive and still ongoing four-year $33.1 million research collaboration of CureVac with Sanofi Pasteur and In-Cell-Art, co-funded by the U.S. Defense Advanced Research Projects Agency (DARPA), as announced in November 2011. Additional details of the collaboration were not disclosed.

About RNActive ® Prophylactic Vaccines

RNActive ® vaccines are a novel technology for the generation and production of safe, efficacious and cost-effective mRNA-based vaccines that are protected against elevated temperature, as well as inadvertent freezing.

In March 2014 CureVac has won the €2 million Vaccine Prize of the European Commission for its RNActive ® vaccine technology. The company received the prize for progress towards a novel technology to bring life-saving vaccines to people across the planet in safe and affordable ways. On the basis of CureVac's technology, it is possible to rapidly produce the mRNA-based vaccines against infectious diseases, and deliver these without requiring a cold chain to the most remote areas of the world.

In vivo data published by CureVac and the Friedrich-Loeffler-Institute in Nature Biotechnology ( Dec 2012) showed that RNActive ® prophylactic vaccines induced balanced, long-lived and protective immunity to influenza A virus infections in various animal models. CureVac operates its own multi-product GMP facility that allows the production of all mRNA vaccines from one common platform.

CureVac's RNActive ® vaccines are based on optimized, antigen-encoding and complexed mRNA molecules that stimulate the immune system. The technology platform is designed to provide potent prophylactic and therapeutic vaccines against infectious diseases and cancer.

About CureVac

CureVac, a clinical stage biopharmaceutical company from Tubingen, Germany, is pioneering the field of RNA-based technology platforms for medical purposes with which RNA is specifically optimized and formulated. Since 2000 the company develops novel mRNA-based cancer immunotherapies and prophylactic vaccines against infectious diseases – both under the brand RNActive ®. Furthermore CureVac develops adjuvants based on non-coding RNAs (RNAdjuvant ®) for enhancing the immune response of other vaccines.

CureVac's technology platform allows overcoming limitations such as the instability of single-stranded RNA, including mRNA. By optimizing the molecule, its stability is improved while translation levels are enhanced without changing the amino acid sequence of the corresponding protein. CureVac only uses naturally occurring nucleotides as building blocks for its mRNA-based products. The immunogenicity of the molecule is achieved by proprietary formulations.

1 of 2

Select the service that is right for you!

Action Alerts PLUS
Try it NOW

Jim Cramer and Stephanie Link actively manage a real portfolio and reveal their money management tactics while giving advanced notice before every trade.

Product Features:
  • $2.5+ million portfolio
  • Large-cap and dividend focus
  • Intraday trade alerts from Cramer
  • Weekly roundups
TheStreet Quant Ratings
Try it NOW
Only $49.95/yr

Access the tool that DOMINATES the Russell 2000 and the S&P 500.

Product Features:
  • Buy, hold, or sell recommendations for over 4,300 stocks
  • Unlimited research reports on your favorite stocks
  • A custom stock screener
  • Upgrade/downgrade alerts
Stocks Under $10
Try it NOW

David Peltier, uncovers low dollar stocks with extraordinary upside potential that are flying under Wall Street's radar.

Product Features:
  • Model portfolio
  • Stocks trading below $10
  • Intraday trade alerts
  • Weekly roundups
Dividend Stock Advisor
Try it NOW

Jim Cramer's protege, David Peltier, identifies the best of breed dividend stocks that will pay a reliable AND significant income stream.

Product Features:
  • Diversified model portfolio of dividend stocks
  • Alerts when market news affect the portfolio
  • Bi-weekly updates with exact steps to take - BUY, HOLD, SELL
Real Money Pro
Try it NOW

All of Real Money, plus 15 more of Wall Street's sharpest minds delivering actionable trading ideas, a comprehensive look at the market, and fundamental and technical analysis.

Product Features:
  • Real Money + Doug Kass Plus 15 more Wall Street Pros
  • Intraday commentary & news
  • Ultra-actionable trading ideas
Options Profits
Try it NOW

Our options trading pros provide daily market commentary and over 100 monthly option trading ideas and strategies to help you become a well-seasoned trader.

Product Features:
  • 100+ monthly options trading ideas
  • Actionable options commentary & news
  • Real-time trading community
  • Options TV
To begin commenting right away, you can log in below using your Disqus, Facebook, Twitter, OpenID or Yahoo login credentials. Alternatively, you can post a comment as a "guest" just by entering an email address. Your use of the commenting tool is subject to multiple terms of service/use and privacy policies - see here for more details.
Submit an article to us!


DOW 17,804.80 +26.65 0.15%
S&P 500 2,070.65 +9.42 0.46%
NASDAQ 4,765.38 +16.9840 0.36%

Brokerage Partners

Rates from

  • Mortgage
  • Credit Cards
  • Auto

Free Newsletters from TheStreet

My Subscriptions:

After the Bell

Before the Bell

Booyah! Newsletter

Midday Bell

TheStreet Top 10 Stories

Winners & Losers

Register for Newsletters
Top Rated Stocks Top Rated Funds Top Rated ETFs