This Day On The Street
Continue to site right-arrow
ADVERTISEMENT
This account is pending registration confirmation. Please click on the link within the confirmation email previously sent you to complete registration.
Need a new registration confirmation email? Click here
Stocks Under $10 with 50-100% upside potential - 14 days FREE!

PharmAthene Presents New SparVaxA® Anthrax Vaccine Data At The FDA Medical Countermeasures Initiative Symposium

Stocks in this article: PIP

ANNAPOLIS, Md., June 4, 2014 /PRNewswire/ -- PharmAthene, Inc. (NYSE MKT: PIP) announced today that new data from its SparVax ® anthrax vaccine program were recently presented at the 2014 U.S. Food and Drug Administration (FDA) Medical Countermeasures Initiative (MCMi) Regulatory Science Symposium in Silver Spring, MD.

In a presentation entitled, " Recombinant Protective Antigen Vaccine (SparVax ®) Provides Protection Equivalent to BioThrax ® Against Lethal Challenge with Bacillus anthracis in New Zealand White Rabbits," Dr. Sherry Crowe, Director, Immunology for PharmAthene, presented survival and toxin neutralization assay (TNA) results from a non-clinical anthrax aerosol challenge model.

In this study, three groups of twenty New Zealand White (NZW) rabbits were vaccinated with SparVax ® via intramuscular injection, on study days 0 and 28 at doses of 3, 9, or 27 micrograms.  In addition, twenty animals were vaccinated with BioThrax ®, the currently-licensed anthrax vaccine.  On the 70 th day of the study, the NZW rabbits were challenged with a lethal dose of aerosolized anthrax spores.

The results of the study demonstrated 100% survival (i.e. equivalent protection) of SparVax ® compared to BioThrax ®.  In addition, the preliminary TNA data showed that the antibody titers for SparVax ® in this study were up to 2-fold higher than BioThrax ®, demonstrating that SparVax® is at least equivalent to BioThrax ® as measured by either survival or TNA using the benchmark NZW rabbit model.

Eric Richman, President and Chief Executive Officer, remarked, "These latest data provide additional supportive evidence of the potential efficacy of SparVax ® as a novel next-generation recombinant protective antigen (rPA)-based anthrax vaccine. One of the requirements for licensure of rPA vaccines is equivalency relative to the current vaccine, so we are encouraged by these results. We are also especially intrigued by the TNA data, which show elevated antibody titers (up to 2-fold higher) for SparVax ® as compared to BioThrax ®, suggesting the potential for a more potent immune response following vaccination with SparVax ®."

In a second poster presentation entitled " Imaging Capillary Electrophoresis Discriminates Slow from Fast Asparagine Deamidation that may Predict Potency for Recombinant Protective Antigen Anthrax Vaccines," Dr. Bradford Powell, Director, Analytical Sciences, presented new analytical data for SparVax ® evaluating the structural characteristics of rPA relative to biological activity.  The ongoing expansion of this body of analytical work by Dr. Powell's team will assist PharmAthene in constructing a reliable stability model that will be useful in predicting the potential shelf life of the rPA anthrax vaccine. 

PharmAthene's rPA anthrax vaccine program has been funded in whole or in part with federal funds from the National Institute of Allergy and Infectious Disease, National Institutes of Health and the Biomedical Advanced Research and Development Authority (BARDA).

1 of 2

Select the service that is right for you!

COMPARE ALL SERVICES
Action Alerts PLUS
Try it NOW

Jim Cramer and Stephanie Link actively manage a real portfolio and reveal their money management tactics while giving advanced notice before every trade.

Product Features:
  • $2.5+ million portfolio
  • Large-cap and dividend focus
  • Intraday trade alerts from Cramer
  • Weekly roundups
TheStreet Quant Ratings
Try it NOW
Only $49.95/yr

Access the tool that DOMINATES the Russell 2000 and the S&P 500.

Product Features:
  • Buy, hold, or sell recommendations for over 4,300 stocks
  • Unlimited research reports on your favorite stocks
  • A custom stock screener
  • Upgrade/downgrade alerts
Stocks Under $10
Try it NOW

David Peltier, uncovers low dollar stocks with extraordinary upside potential that are flying under Wall Street's radar.

Product Features:
  • Model portfolio
  • Stocks trading below $10
  • Intraday trade alerts
  • Weekly roundups
Dividend Stock Advisor
Try it NOW

Jim Cramer's protege, David Peltier, identifies the best of breed dividend stocks that will pay a reliable AND significant income stream.

Product Features:
  • Diversified model portfolio of dividend stocks
  • Alerts when market news affect the portfolio
  • Bi-weekly updates with exact steps to take - BUY, HOLD, SELL
Real Money Pro
Try it NOW

All of Real Money, plus 15 more of Wall Street's sharpest minds delivering actionable trading ideas, a comprehensive look at the market, and fundamental and technical analysis.

Product Features:
  • Real Money + Doug Kass Plus 15 more Wall Street Pros
  • Intraday commentary & news
  • Ultra-actionable trading ideas
Options Profits
Try it NOW

Our options trading pros provide daily market commentary and over 100 monthly option trading ideas and strategies to help you become a well-seasoned trader.

Product Features:
  • 100+ monthly options trading ideas
  • Actionable options commentary & news
  • Real-time trading community
  • Options TV
To begin commenting right away, you can log in below using your Disqus, Facebook, Twitter, OpenID or Yahoo login credentials. Alternatively, you can post a comment as a "guest" just by entering an email address. Your use of the commenting tool is subject to multiple terms of service/use and privacy policies - see here for more details.
Submit an article to us!

Markets

DOW 18,053.71 +23.50 0.13%
S&P 500 2,088.77 +6.89 0.33%
NASDAQ 4,806.8590 +33.3870 0.70%

Brokerage Partners

Rates from Bankrate.com

  • Mortgage
  • Credit Cards
  • Auto

Free Newsletters from TheStreet

My Subscriptions:

After the Bell

Before the Bell

Booyah! Newsletter

Midday Bell

TheStreet Top 10 Stories

Winners & Losers

Register for Newsletters
Top Rated Stocks Top Rated Funds Top Rated ETFs