This Day On The Street
Continue to site
This account is pending registration confirmation. Please click on the link within the confirmation email previously sent you to complete registration.
Need a new registration confirmation email? Click here

Amgen And Onyx Data At ASCO 2014 Highlight Oncology Pipeline And Portfolio

THOUSAND OAKS, Calif. and SOUTH SAN FRANCISCO, Calif., May 27, 2014 /PRNewswire/ -- Amgen (NASDAQ:AMGN) and its subsidiary Onyx Pharmaceuticals, Inc., today announced data from several studies of both pipeline and marketed products will be presented at the 50 th Annual Meeting of the American Society of Clinical Oncology (ASCO) being held May 30-June 3 in Chicago. The research that will be presented demonstrates Amgen's and Onyx's continued progress in developing treatments for patients with difficult-to-treat cancers, as well as investigating new uses and areas of interest for their current cancer care treatments.

"The data presented at ASCO this year is a testament to our focus on addressing unmet needs and the strategic acquisitions that we have made, such as Onyx, to further our leadership in oncology," said Sean E. Harper, M.D., executive vice president of Research and Development at Amgen. "Amgen and Onyx continue to be on the cutting edge of research and are constantly looking for innovative approaches to tackle some of the toughest cancers."

During the meeting, Amgen and Onyx will present results from more than 45 studies in 17 different cancers, including six oral presentations and 25 posters across 11 oncology molecules. Abstracts are currently available on the ASCO website at .

Amgen Data Includes: Blinatumomab (AMG 103)Amgen will present results from the following pivotal Phase 2 study assessing blinatumomab, a bispecific T cell engager (BiTE ®) antibody, in patients with acute lymphoblastic leukemia (ALL).
  • Confirmatory open-label, single-arm, multicenter Phase 2 study of the BiTE ® antibody blinatumomab in patients with relapsed/refractory B-precursor acute lymphoblastic leukemiaAbstract No. 7005, Oral Abstract Session, Tuesday, June 3, 9:45 a.m. to 12:45 p.m. CT, E354a

Talimogene Laherparepvec New data will be presented in patients with metastatic melanoma. Talimogene laherparepvec data to be presented at ASCO includes monotherapy data from the Phase 3 OPTiM trial as well as data on the combination of talimogene laherparepvec with another immunotherapy.
  • Primary analysis of a Phase 1b multicenter trial to evaluate safety and efficacy of talimogene laherparepvec (T-VEC) and ipilimumab (ipi) in previously untreated, unresected, stage IIIB-IV melanoma  Abstract No. 9029, Poster Highlights Session, Monday, June 2, 8 a.m. to 11 a.m. CT, E354b  and 11:30 a.m. to 12:45 p.m. CT, E Arie Crown Theater
  • Patterns of durable response with intralesional talimogene laherparepvec (T-VEC): Results from a Phase 3 trial in patients with stage IIIB-IV melanoma Abstract No. 9026, Poster Highlights Session, Monday, June 2, 8 a.m. to 11 a.m. CT, E354b and 11:30 a.m. to 12:45 p.m. CT, E Arie Crown Theater
  • Primary overall survival (OS) from OPTiM, a randomized Phase 3 trial of talimogene laherparepvec (T-VEC) versus subcutaneous (SC) granulocyte-macrophage colony-stimulating factor (GM-CSF) for the treatment (tx) of unresected stage IIIB/C and IV melanomaAbstract No. 9008a, Oral Abstract Session, Monday, June 2, 3 p.m. to 6 p.m. CT, E Arie Crown Theater

Vectibix ® (panitumumab) Two studies to be presented at ASCO will provide more detailed information about predictive biomarkers in patients with metastatic colorectal cancer (mCRC). On May 23, 2014, the U.S. Food and Drug Administration (FDA) approved Vectibix plus FOLFOX chemotherapy as a first-line treatment for patients with wild-type KRAS mCRC. With this approval, Vectibix became the first and only biologic therapy indicated for use with FOLFOX, one of the most commonly used chemotherapy regimens in the first-line treatment of wild-type KRAS mCRC patients.
  • Survival outcomes in the PRIME study for patients with RAS/BRAF wild-type (WT) metastatic colorectal cancer (mCRC), by baseline Eastern Cooperative Oncology Group (ECOG) performance status Abstract No. 3557, General Poster Session, Saturday, May 31, 8 a.m. to 11:45 a.m. CT, S Hall A2
  • Extended RAS analysis and subsequent anti-EGFR and anti-VEGF treatment (tx) in PEAK: a 1st-line Phase 2 study of FOLFOX6 + panitumumab (pmab) or bevacizumab (bev) in metastatic colorectal cancer  Abstract No. 3629, General Poster Session, Saturday, May 31, 8 a.m. to 11:45 a.m. CT, S Hall A2

XGEVA ® (denosumab)Amgen will present data from imaging studies that reveal early, sustained and progressive activity in giant cell tumor of bone (GCTB) and additional data regarding the prevention of skeletal related events (SREs) in patients with bone metastases.
  • Response to treatment with denosumab in patients with giant cell tumor of bone (GCTB): FDG PET results from two Phase 2 trialsAbstract No. 10505, Oral Abstract Session, Sunday, June 1, 8 a.m. to 11 a.m. CT, S406
  • Effect of denosumab versus zoledronic acid (ZA) at preventing skeletal-related events (SREs) in patients with metastatic bone disease: subgroup analyses by baseline characteristicsAbstract No. 9501, Oral Abstract Session,  Monday, June 2, 3 p.m. to 6 p.m. CT, E253
  • Symptomatic skeletal events (SSE) in patients with advanced prostate cancer: results from a Phase 3 trial of denosumab for the prevention of skeletal-related events Abstract No. 5075, General Poster Session, Monday, June 2, 1:15 p.m. to 5 p.m. CT, S Hall A2

Onyx Data Includes: Kyprolis ® (carfilzomib)New data will be presented from the CHAMPION-1 study evaluating the safety and efficacy of once-weekly carfilzomib with dexamethasone for patients with relapsed or refractory multiple myeloma.
  • Results of the dose-escalation portion of a Phase 1/2 study (CHAMPION-1) investigating weekly carfilzomib in combination with dexamethasone for patients with relapsed or refractory multiple myelomaAbstract No. 8594, General Poster Session, Monday, June 2, 1:15 p.m. to 5 p.m. CT, S Hall A2

Amgen Post-ASCO Summary Webcast  Amgen will hold a post-ASCO summary webcast on Tuesday, June 3, 2014, at 1 p.m. PT. Sean E. Harper, M.D., executive vice president of Research and Development at Amgen, along with members of Amgen's clinical development team will participate to discuss data presented at ASCO and Amgen's broader oncology portfolio of products. 

Live audio of the conference call will be simultaneously broadcast over the Internet and will be available to members of the news media, investors and the general public. 

1 of 9

Check Out Our Best Services for Investors

Action Alerts PLUS

Portfolio Manager Jim Cramer and Director of Research Jack Mohr reveal their investment tactics while giving advanced notice before every trade.

Product Features:
  • $2.5+ million portfolio
  • Large-cap and dividend focus
  • Intraday trade alerts from Cramer
Quant Ratings

Access the tool that DOMINATES the Russell 2000 and the S&P 500.

Product Features:
  • Buy, hold, or sell recommendations for over 4,300 stocks
  • Unlimited research reports on your favorite stocks
  • A custom stock screener
Stocks Under $10

David Peltier uncovers low dollar stocks with serious upside potential that are flying under Wall Street's radar.

Product Features:
  • Model portfolio
  • Stocks trading below $10
  • Intraday trade alerts
14-Days Free
Only $9.95
14-Days Free
Dividend Stock Advisor

David Peltier identifies the best of breed dividend stocks that will pay a reliable AND significant income stream.

Product Features:
  • Diversified model portfolio of dividend stocks
  • Updates with exact steps to take - BUY, HOLD, SELL
Trifecta Stocks

Every recommendation goes through 3 layers of intense scrutiny—quantitative, fundamental and technical analysis—to maximize profit potential and minimize risk.

Product Features:
  • Model Portfolio
  • Intra Day Trade alerts
  • Access to Quant Ratings
Real Money

More than 30 investing pros with skin in the game give you actionable insight and investment ideas.

Product Features:
  • Access to Jim Cramer's daily blog
  • Intraday commentary and news
  • Real-time trading forums
Only $49.95
14-Days Free
14-Days Free
AAPL $94.22 -1.00%
FB $117.73 0.26%
GOOG $696.72 0.63%
TSLA $226.36 -2.60%
YHOO $35.87 -0.39%


Chart of I:DJI
DOW 17,655.06 -95.85 -0.54%
S&P 500 2,052.67 -10.70 -0.52%
NASDAQ 4,736.0420 -27.1820 -0.57%

Free Reports

Top Rated Stocks Top Rated Funds Top Rated ETFs