The trial will determine the safety, tolerability and preliminary efficacy of nivolumab, Bristol-Myers' investigational PD-1 immune checkpoint inhibitor, and varlilumab, Celldex's CD27 targeting investigational antibody in a Phase 1/2 study. The study will explore multiple tumor types, which potentially include non-small cell lung cancer, metastatic melanoma, ovarian, colorectal and squamous cell head and neck cancers.
Bristol-Myers Squibb will make a one-time payment of $5 million to Celldex under the terms of the agreement, and the two companies will share development costs. Celldex will conduct the Phase 1/2 study, which should start in the fourth quarter of 2014.
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