This Day On The Street
Continue to site
This account is pending registration confirmation. Please click on the link within the confirmation email previously sent you to complete registration.
Need a new registration confirmation email? Click here

Regulus Presents Positive Preclinical Data On MiR-21 And MiR-221 Oncology Programs In Oral And Poster Presentations At AACR 2014 Annual Meeting

LA JOLLA, Calif., April 7, 2014 /PRNewswire/ -- Regulus Therapeutics Inc. (NASDAQ:RGLS), a biopharmaceutical company leading the discovery and development of innovative medicines targeting microRNAs, today announced that three abstracts will be presented in poster presentation sessions during the American Association for Cancer Research (AACR) Annual Meeting, which will be held April 5-9, 2014 in San Diego, CA. An oral presentation will also be presented by Regulus' strategic alliance partner, Sanofi. Data to be presented include preclinical studies investigating the therapeutic potential of targeting microRNA-21 ("miR-21") and microRNA-221 ("miR-221") for the treatment of hepatocellular carcinoma ("HCC"), the most common form of liver cancer, and biomarker discovery studies evaluating the pharmacodynamics signature for assessing miR-221 inhibition and microRNA expression in tumor tissues in mouse models of HCC.  Each poster, after the time of its presentation, can be accessed on the investor relations page of Regulus' website,
  • Poster Session on miR-221 - April 7, 2014 8:00 a.m. - 12:00 p.m. PDT
    • miR-221: a Potential Therapeutic Target for Hepatocellular Carcinoma
    • A miR-221 Multigene Pharmacodynamics Signature for Assessing miR-221 Inhibition
  • Oral Presentation by Sanofi on miR-21 – April 8, 2014 3:35 p.m. PDT
    • Targeting microRNA-21 in Hepatocellular Carcinoma
  • Poster Session on microRNA Expression - April 9, 2014 8:00 a.m. - 12:00 p.m. PDT
    • Serum microRNAs Reflect microRNA Expression in Tumor Tissues as Well as Systemic Response to Disease in HRAS-driven Mouse Models of HCC

"Utilizing both genetic and pharmacological approaches, the data to be presented at AACR provide further evidence that miR-21 and miR-221 are validated preclinical targets for the treatment of hepatocellular carcinoma," said Neil W. Gibson, Ph.D., Chief Scientific Officer of Regulus. "In addition, we've made progress to develop gene signatures that enable demonstration of target inhibition in tumor tissues.  We believe these gene signatures and the overall approach enable Regulus to demonstrate proof of mechanism in preclinical studies which may be translated into useful biomarker signatures in potential future clinical trials."

Update on Regulus' Liver Cancer Intellectual Property Estate

As part of Regulus' rich intellectual property estate, Regulus controls patent rights related to the modulation of multiple different microRNAs for the treatment of liver cancer. Regulus has already received patents in the United States for targeting multiple different microRNAs, including miR-21 and miR-221/222, for the treatment of liver cancer. Also included in the Regulus portfolio are fundamental patent rights claiming methods of treating liver cancer with mimics of microRNA-34a, one of the most well-validated tumor suppressor microRNAs. 

Today, Regulus is pleased to announce receipt of a Decision to Grant a Patent from the Japan Patent Office for the use of anti-miRs targeting multiple different microRNAs, including miR-21 and miR-222, for the treatment of liver cancer. 

1 of 3

Check Out Our Best Services for Investors

Action Alerts PLUS

Portfolio Manager Jim Cramer and Director of Research Jack Mohr reveal their investment tactics while giving advanced notice before every trade.

Product Features:
  • $2.5+ million portfolio
  • Large-cap and dividend focus
  • Intraday trade alerts from Cramer
Quant Ratings

Access the tool that DOMINATES the Russell 2000 and the S&P 500.

Product Features:
  • Buy, hold, or sell recommendations for over 4,300 stocks
  • Unlimited research reports on your favorite stocks
  • A custom stock screener
Stocks Under $10

David Peltier uncovers low dollar stocks with serious upside potential that are flying under Wall Street's radar.

Product Features:
  • Model portfolio
  • Stocks trading below $10
  • Intraday trade alerts
14-Days Free
Only $9.95
14-Days Free
Dividend Stock Advisor

David Peltier identifies the best of breed dividend stocks that will pay a reliable AND significant income stream.

Product Features:
  • Diversified model portfolio of dividend stocks
  • Updates with exact steps to take - BUY, HOLD, SELL
Trifecta Stocks

Every recommendation goes through 3 layers of intense scrutiny—quantitative, fundamental and technical analysis—to maximize profit potential and minimize risk.

Product Features:
  • Model Portfolio
  • Intra Day Trade alerts
  • Access to Quant Ratings
Real Money

More than 30 investing pros with skin in the game give you actionable insight and investment ideas.

Product Features:
  • Access to Jim Cramer's daily blog
  • Intraday commentary and news
  • Real-time trading forums
Only $49.95
14-Days Free
14-Days Free
AAPL $95.01 1.05%
FB $99.75 -4.15%
GOOG $682.74 -0.12%
TSLA $147.99 -8.99%
YHOO $27.05 -3.29%


Chart of I:DJI
DOW 16,027.05 -177.92 -1.10%
S&P 500 1,853.44 -26.61 -1.42%
NASDAQ 4,283.7530 -79.3910 -1.82%

Free Reports

Top Rated Stocks Top Rated Funds Top Rated ETFs